Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 12,011-12,020 of 12,052 results
The Journal of Neuroscience, 2004 • November 3, 2004
This study investigates the feasibility of using superparamagnetic iron oxide (SPIO)-labeled Schwann cells (SCs) and olfactory ensheathing cells (OECs) for non-invasive tracking via MRI after transpla...
KEY FINDING: SCs and OECs efficiently internalize dextran-coated SPIO from the culture medium by fluid phase pinocytosis.
J Neurol Neurosurg Psychiatry, 2004 • November 1, 2004
This study evaluated the long-term effects of intrathecal baclofen (ITB) on impairment, disability, and quality of life in patients with severe spasticity of spinal origin. The results showed that ITB...
KEY FINDING: Long-term intrathecal baclofen resulted in significant improvement in clinical efficacy, specifically reducing spasticity and spasms.
Journal of NeuroEngineering and Rehabilitation, 2004 • October 25, 2004
This study evaluated the effect of passive leg movements on blood circulation during tilt table testing in healthy adults. Two types of passive leg movements were tested: stepping and cycling. The res...
KEY FINDING: Passive stepping movements on the tilt stepper significantly reduced the occurrence of near-syncope or syncope compared to the traditional tilt table.
J Comp Neurol, 2004 • October 25, 2004
This study investigates the effects of conditioning lesions (CLs) on axonal regeneration of descending brain neurons in spinal-cord-transected larval lamprey. The researchers found that CLs at 30% bod...
KEY FINDING: Conditioning lesions at 30% body length, with a two-week delay before a test lesion and a four-week recovery period, significantly enhanced axonal regeneration of descending brain neurons.
The Journal of Experimental Medicine, 2004 • October 18, 2004
This study demonstrates that a single neuroinflammatory lesion in the spinal cord induces axonal remodeling at multiple levels within the motor system. The remodeling includes local interneuron sprout...
KEY FINDING: Local interneurons near the spinal cord lesion sprout new connections, indicated by increased expression of c-Jun and GAP43.
The Journal of Neuroscience, 2004 • September 29, 2004
This study investigates the potential of olfactory ensheathing cells (OECs) to repair spinal cord injuries. OECs from adult transgenic rats were transplanted into a dorsal spinal cord transection lesi...
KEY FINDING: Transplanted OECs survived within the lesion zone and oriented longitudinally along axons bridging the transection site.
The Journal of Neuroscience, 2004 • September 29, 2004
This study examined gene expression patterns in rat spinal cords after injury, comparing two different rat strains to understand the molecular response to SCI over time (up to 90 days). Microarray ana...
KEY FINDING: A highly orchestrated tissue repair and remodeling repertoire with a prominent cutaneous wound healing signature is conserved between two widely differing rat strains after spinal cord injury.
The Journal of Neuroscience, 2004 • September 8, 2004
This study investigates the role of L1.1, a homolog of the mammalian recognition molecule L1, in spinal cord regeneration in adult zebrafish. Using a morpholino-based approach, the researchers reduced...
KEY FINDING: Reducing L1.1 protein expression impairs locomotor recovery in adult zebrafish after spinal cord transection.
BMC Genomics, 2004 • August 13, 2004
The study developed expressed sequence tags (ESTs) for the Mexican axolotl (Ambystoma mexicanum) and the Eastern tiger salamander (A. tigrinum tigrinum) from various tissues, including regenerating li...
KEY FINDING: Approximately 40,000 cDNA sequences were isolated for A. mexicanum and A. t. tigrinum from various tissues.
The Journal of Neuroscience, 2004 • July 21, 2004
The study developed an in vitro assay that mimics the PG gradient phenotype in the glial scar, demonstrating that adult DRGs form dystrophic endings morphologically and behaviorally similar to those i...
KEY FINDING: PGs can lead to growth cone dystrophy and that, surprisingly, supposedly sterile dystrophic endings are extraordinarily dynamic.