Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,801-11,810 of 12,052 results
Neurosci Lett, 2008 • June 27, 2008
This study demonstrated that epidural stimulation (ES) combined with quipazine administration in spinal cord transected adult rats can improve the quality and consistency of hindlimb stepping. The mai...
KEY FINDING: The combination of quipazine and epidural stimulation resulted in a significantly greater number of plantar steps compared to either intervention alone.
Journal of Neuroinflammation, 2008 • June 25, 2008
This study investigates the expression of complement mRNAs and the presence of complement proteins associated with polymorphonuclear leukocytes (PMNs) after spinal cord injury (SCI). Cultured PMNs exp...
KEY FINDING: Stimulated or unstimulated PMNs expressed mRNAs encoding for C1q, C3, and C4, but not C5, C6, C7 or C9 in culture. Complement protein C1q or C3 was also detected in less than 30% of cultured PMNs.
Neurosci Lett., 2008 • June 20, 2008
The study investigates the neuroprotective effects of rolipram, a PDE4 inhibitor, on oligodendrocytes following contusive cervical spinal cord injury (SCI) in rats. Results demonstrate that oligodendr...
KEY FINDING: Spinal cord oligodendrocytes express three PDE4 subtypes (PDE4A, B, D), while microglia express only PDE4B.
The Journal of Neuroscience, 2008 • June 4, 2008
The study examined the characteristics of hindlimb EMG activity evoked in response to epidural stimulation at the S1 spinal cord segment in complete midthoracic spinal cord-transected rats at differen...
KEY FINDING: A progressive and phase-dependent modulation of monosynaptic (middle) and long-latency (late) stimulation-evoked EMG responses was observed throughout the step cycle.
Spinal Cord, 2008 • June 1, 2008
This study examined the prevalence, intensity, and interference of pain in individuals with spinal cord injury (SCI). It investigated the relationship between pain characteristics and patient demograp...
KEY FINDING: Persons with higher level injuries were more likely to report upper extremity pain than persons with paraplegic injuries.
J Neural Eng, 2008 • June 1, 2008
This study demonstrates that a noninvasive BCI using EEG can provide people with multidimensional movement and selection capabilities, emulating mouse operation. The results show that users can learn ...
KEY FINDING: People can learn to use scalp-recorded EEG rhythms to move a cursor in two dimensions to reach a target and then to select the target.
J Neural Eng, 2008 • June 1, 2008
The study demonstrated that extra-spinal electrical stimulation, particularly when amplitude-modulated, can induce coordinated hindlimb movements in cats, including flexion, extension, and stepping. T...
KEY FINDING: Stimulation location influences movement type: rostral segments (L5) induced flexion, caudal segments (L7/S1) induced extension.
J Appl Physiol, 2008 • June 1, 2008
This study assessed the effects of chronic expiratory muscle stimulation, via lower thoracic spinal cord stimulation, in a chronic cat model of spinal cord injury. The results indicate that intermitte...
KEY FINDING: Chronic electrical stimulation prevented significant reductions in expiratory muscle weight and fiber cross-sectional area.
Exp Neurol, 2008 • June 1, 2008
This study investigates the effect of human adult bone marrow-derived somatic cells (hABM-SC) on stroke recovery in rats. hABM-SC treatment led to improved forelimb function on a skilled motor task, i...
KEY FINDING: hABM-SC therapy after stroke in rats led to significant functional recovery in a skilled forelimb task.
IEEE Trans Neural Syst Rehabil Eng., 2008 • June 1, 2008
This study used a musculoskeletal model to simulate the effects of FES on shoulder and elbow function in individuals with C5 SCI. The model helped identify a set of three 'essential' muscles (serratus...
KEY FINDING: A muscle set consisting of the serratus anterior, infraspinatus and triceps would enable the greatest range of relevant movements.