Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,741-11,750 of 12,052 results
JOURNAL OF NEUROTRAUMA, 2009 • January 1, 2009
This study introduces the LISA-Vibraknife as a precise tool for creating graded spinal cord injuries (SCI) in mice, enabling researchers to control lesion depth accurately. The study demonstrated that...
KEY FINDING: Functional deficits increased significantly as the depth of the spinal cord lesion increased, demonstrating a clear relationship between injury severity and functional impairment.
IEEE Trans Biomed Eng, 2009 • January 1, 2009
This paper describes a new method for designing feedforward controllers for multiple-muscle, multiple-degree-of-freedom, motor system neural prostheses. We tested the method experimentally in ten able...
KEY FINDING: Good control of isometric force was achieved in both degrees of freedom, with RMS errors less than 10% of the force range in seven experiments.
Prog Brain Res, 2009 • January 1, 2009
Spinal cord injury (SCI) research has made significant advances, yet a unified vision is needed to integrate these findings for improved patient outcomes. Effective strategies involve combining treatm...
KEY FINDING: After a spinal cord injury, pathways can be rendered either hyper- or hypoexcitable. Successful rehabilitation requires properly managing the level of excitability, as necessary, of each of the critical locomotor circuits.
Conf Proc IEEE Eng Med Biol Soc, 2009 • January 1, 2009
The study focuses on the development and application of robotic lower limb exoskeletons, particularly those controlled by proportional myoelectric control. This control method uses the wearer's muscle...
KEY FINDING: Healthy humans can quickly adjust to walking with robotic ankle exoskeletons, ultimately using less energy.
Conf Proc IEEE Eng Med Biol Soc, 2009 • January 1, 2009
The Tongue Drive System (TDS) is a wireless assistive technology that enables individuals with severe disabilities to control devices using tongue movements. An external TDS (eTDS) prototype was devel...
KEY FINDING: All subjects could successfully perform computer access tasks, such as controlling a mouse cursor and playing computer games.
Exp Neurol, 2009 • January 1, 2009
This study investigated the potential of IGF-I gene delivery to promote corticospinal axon regeneration and neuronal survival after spinal cord injury in adult rats. IGF-I secreting cell grafts were u...
KEY FINDING: IGF-I secreting cell grafts promoted growth of raphespinal and coerulospinal axons into the lesion/graft site after C3 dorsal column transections in adult rats.
Eur J Neurosci, 2009 • January 1, 2009
This study investigated whether a coculture of endothelial cells (ECs) and neural progenitor cells (NPCs) in a biodegradable implant could promote angiogenesis and formation of the blood-spinal cord b...
KEY FINDING: The coculture implant led to a four fold increase in functional vessels compared to the lesion control, implant alone, or implant plus NPCs groups.
JOURNAL OF NEUROTRAUMA, 2009 • January 1, 2009
This study demonstrates that ibuprofen promotes recovery from spinal cord contusion through a complex mechanism including axonal sprouting, neuroprotection, and raphespinal regeneration. Ibuprofen tre...
KEY FINDING: Ibuprofen reduces ligand-induced Rho signaling and myelin-induced inhibition of neurite outgrowth in vitro.
The Journal of Neuroscience, 2008 • December 17, 2008
This study investigates the role of C1q, a component of the classical complement pathway, in spinal cord injury (SCI) using C1q knock-out (KO) mice on a complement-sufficient background (BUB). The key...
KEY FINDING: BUB C1q KO mice exhibited greater locomotor recovery compared with BUB WT mice.
The Journal of Neuroscience, 2008 • December 10, 2008
This study investigates the role of MMP-9 in glial scar formation and astrocyte migration following spinal cord injury. The findings suggest that MMP-9 facilitates glial scar formation and astrocyte m...
KEY FINDING: Wild-type mice developed a more severe glial scar compared to MMP-9 null mice after spinal cord injury, indicating MMP-9's role in glial scar formation.