Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,731-11,740 of 12,052 results
Molecular Therapy, 2009 • February 1, 2009
The study engineered plasmid-loaded multiple channel bridges for spinal cord regeneration. These bridges support cellular processes and promote gene transfer at the injury site. Subcutaneous implantat...
KEY FINDING: Plasmid-loaded bridges support substantial cell infiltration and aligned cells within the channels.
The Journal of Neuroscience, 2009 • January 28, 2009
This study demonstrates that the EGF receptor, when activated in astrocytes, triggers a signaling pathway involving Akt, Tuberin, Rheb, and mTOR. The research also shows that this pathway is functiona...
KEY FINDING: EGF activates the mTOR pathway in cultured adult spinal cord astrocytes through Akt-mediated phosphorylation of Tuberin, leading to Rheb activation.
Brain Res Bull, 2009 • January 15, 2009
The spinal cord has the potential to reorganize after injury and utilize remaining peripheral input to control stepping and standing. Motor training, especially with variability in the task, can impro...
KEY FINDING: Motor training can improve the coordination of motor pools within and among limbs after spinal cord injury.
BMC Biology, 2009 • January 13, 2009
Microarray analysis and 454 cDNA sequencing were used to identify nerve-dependent and independent gene expression changes during limb regeneration in the Mexican axolotl. The results show that limb re...
KEY FINDING: Considerable similarity was observed between NR and DL transcriptional programs at 5 and 14 days post amputation (dpa).
BMC Genomics, 2009 • January 13, 2009
This study provides the first DNA sequence data from a large salamander genome, revealing that genic regions, particularly introns, are significantly expanded compared to other vertebrates. The analys...
KEY FINDING: Axolotl introns are significantly longer (10x) than orthologous vertebrate introns, contributing substantially to the large genome size.
BioMed Central, 2009 • January 6, 2009
This study demonstrates that the sea cucumber Holothuria glaberrima can fully regenerate its radial nerve cord (RNC) after transection, restoring its morphology and cellular composition within a month...
KEY FINDING: Holothuria glaberrima can regenerate its radial nerve cord within a month following transection.
JoVE, 2009 • January 1, 2009
One of the goals of our research is to promote axon regeneration to restore connectivity across the lesion site. Importantly, the peripheral nerve grafting approach is effective in promoting regenerat...
KEY FINDING: Ascending and descending spinal axons will enter the graft, grow in a relatively straight line parallel to the length of the graft and extend to the distal end of the graft at a rate of approximately 1 mm per day.
Results Probl Cell Differ, 2009 • January 1, 2009
Axon regeneration in the mature mammalian central nervous system (CNS) is extremely limited after injury. This situation differs from that in the mammalian peripheral nervous system (PNS), where long-...
KEY FINDING: The PNS environment is stimulatory and/or the CNS environment is inhibitory for axon growth.
Am J Phys Med Rehabil, 2009 • January 1, 2009
This study identified several physical and logistical barriers to DXA scanning for individuals with SCI, including scanner design, room size, and staffing requirements. The process of DXA scanning is ...
KEY FINDING: Scanner design and configuration in the scanning room limited accessibility, increased typical scanning time, and made additional staff necessary.
Arch Phys Med Rehabil, 2009 • January 1, 2009
This study identified the association of risk and protective behaviors for mortality after SCI using prospective cohort design and a priori selection of variables using a general risk model. The study...
KEY FINDING: Smoking, binge drinking, prescription medication use, and less time out of bed are significant behavioral predictors of mortality after SCI.