Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,751-11,760 of 12,052 results
Neural Development, 2008 • December 8, 2008
This study investigates the role of Semaphorin-6A (Sema6A) and its receptors, Plexin-A2 (PlxnA2) and Plexin-A4 (PlxnA4), in the guidance of corticospinal tract (CST) axons. The results show that Sema6...
KEY FINDING: Sema6A mutants exhibit hypoplasia and misrouting of the corticospinal tract, affecting the number of axons reaching the hindbrain and spinal cord.
The Journal of Neuroscience, 2008 • December 3, 2008
The study investigates the role of dendritic spine remodeling in the maintenance of neuropathic pain after spinal cord injury (SCI). SCI leads to altered spine morphologies and distribution in dorsal ...
KEY FINDING: SCI induces dendritic spine remodeling in dorsal horn neurons, characterized by increased spine density, altered spine distribution, and more mature spine morphology.
Am J Phys Med Rehabil, 2008 • December 1, 2008
The study evaluated manual wheelchair propulsion across different level ground conditions to understand the impact of terrain on propulsion biomechanics. The results showed that propulsion forces and ...
KEY FINDING: Propulsion frequency was significantly greater during both concrete conditions than either tile or carpet ground conditions.
JOURNAL OF NEUROTRAUMA, 2008 • December 1, 2008
This study evaluated the effect of active stand training on arterial blood pressure and heart rate and changes in response to orthostatic stress in individuals with SCI. Improvements in resting arteri...
KEY FINDING: Resting arterial blood pressure significantly increased in individuals with cervical SCI after 80 training sessions of stand LT.
J Neurol Phys Ther, 2008 • December 1, 2008
The study documented the screening process and developed habituation procedures for FES-LCE exercise for individuals with SCI. Almost half of the individuals were not eligible for the FES-LCE habituat...
KEY FINDING: Almost half of the individuals interested in participating in the FES-LCE exercise program did not pass the screening phase due to factors such as previous fragility fracture, excessive spasticity, pain, autonomic dysreflexia, or lack of electrical stimulation response.
Eur Spine J, 2009 • November 22, 2008
This review discusses the pathophysiology of SCI and the properties of endogenous and exogenously administered EPO. Animal models that mimic SCI are presented, focusing on traumatic, ischemic, and inf...
KEY FINDING: EPO demonstrates cytoprotection in a variety of tissues, including spinal cord, through activation of multiple signaling pathways.
Glia, 2008 • November 15, 2008
This study introduces a novel in vitro model of the glial scar, generated by combining mechanical trauma and co-culture with meningeal cells using highly differentiated astrocytes. The model effective...
KEY FINDING: Mechanical stretch and co-culture with meningeal cells induced astrocyte reactivity, including stellation, clustering, and GFAP accumulation.
Spine (Phila Pa 1976), 2008 • November 15, 2008
This study evaluates the stability of implanted scaffolds and the extent of kyphoscoliotic deformities after spinal fixation in a rat model of spinal cord injury. The researchers implanted radio-opaqu...
KEY FINDING: Spinal fixation significantly reduced scoliosis in the fixed group (1.89 ± 0.75°) compared to the unfixed group (8.13 ± 2.03°).
The Journal of Neuroscience, 2008 • November 12, 2008
The study demonstrates that degrading CSPGs with ChABC can promote the reorganization of spinal circuitry and restore sensory function after partial deafferentation. Electrophysiological recordings co...
KEY FINDING: ChABC normalizes deafferentation-induced compromise of sensory function. Spared-root-lesioned animals treated with ChABC did not show a deficit in their ability to sense the presence of the tape or the ability to remove the tape on any of the postinjury testing days.
Neuroepidemiology, 2009 • November 8, 2008
This study examined both short- and long-term mortality in a 2-year cohort of veterans with preexisting neurological disorders and subsequent LE amputation in a large integrated US health system. Almo...
KEY FINDING: 43.3% of the 4,720 patients had neurological disorders documented prior to amputation.