Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,661-11,670 of 12,052 results
Journal of NeuroEngineering and Rehabilitation, 2009 • July 3, 2009
This paper presents a simple un-motorized bilateral exoskeleton for swing assistance and training of motor impaired patients. The device consists of two segments – thigh and shank with torsion springs...
KEY FINDING: At 2.0 mph, the device was effective in reducing the maximum hip torque requirement and the knee joint torque during the beginning of the swing.
J Neuropathol Exp Neurol, 2009 • July 1, 2009
The study investigates the effect of co-transplanting embryonic neurons with neurotrophic factors on muscle reinnervation and function after sciatic nerve denervation in rats. The key finding is that ...
KEY FINDING: Adding GDNF, HGF, and IGF-1 to the cell transplant significantly increased motoneuron survival, myelinated axon counts, muscle reinnervation, and evoked EMG compared to cells alone.
J Neurochem, 2009 • July 1, 2009
The study demonstrates that inhibiting NF-κB in astrocytes promotes axonal sparing and sprouting after spinal cord contusion injury, contributing to improved functional recovery. Retrograde tracing sh...
KEY FINDING: Inhibition of NF-κB in astrocytes leads to reduced inflammation and improved functional recovery after spinal cord injury.
Nat Neurosci, 2009 • July 1, 2009
This report demonstrates that chromatin remodeling enzymes HDAC1/2 regulate oligodendrocyte specification and differentiation, at least in part, by inhibiting β-catenin/TCF7L2 complex formation. The s...
KEY FINDING: HDAC1 and HDAC2 are essential for oligodendrocyte formation, and their deletion leads to a complete loss of oligodendrocytes.
TISSUE ENGINEERING: Part A, 2009 • July 1, 2009
The study investigates the use of biodegradable polymer scaffolds loaded with neural stem cells (NSCs) and Schwann cells (SCs) to promote axonal regeneration in a rat model of complete spinal cord tra...
KEY FINDING: Biodegradable scaffolds seeded with NSCs or SCs facilitate regeneration across the transected spinal cord.
JOURNAL OF NEUROTRAUMA, 2009 • July 1, 2009
The study aimed to determine if initiating swim training acutely after spinal cord injury (SCI) is more beneficial than initiating it after 2 weeks. Rats with moderate to severe thoracic contusion SCI...
KEY FINDING: Acute swim training (initiated 3 days post-SCI) is less effective than training initiated at 2 weeks post-injury in improving swimming ability.
Int J Clin Exp Hypn, 2009 • July 1, 2009
The study compared self-hypnosis (HYP) and EMG biofeedback (BIO) for chronic pain management in spinal cord injury (SCI) patients, finding both reduced immediate pain. HYP group showed lasting daily p...
KEY FINDING: Participants in both treatment conditions reported substantial, but similar, decreases in pain intensity from before to after the treatment sessions.
J Orthop Res, 2009 • July 1, 2009
This study evaluated the effect of glial scar resection on recovery after spinal cord injury using contusion and dorsal hemisection models in rats. The results indicated that glial scar resection wors...
KEY FINDING: Glial scar resection did not significantly affect functional recovery in the dorsal hemisection model.
J. Anat., 2009 • June 24, 2009
This study investigated the effect of cyclosporin A (CsA) on functional recovery and the cellular environment following spinal cord contusion injury in rats. CsA was administered to rats after a moder...
KEY FINDING: CsA treatment resulted in a short-term functional improvement at 3 weeks post-injury in the left hindlimbs of rats.
Cell Mol Neurobiol, 2009 • June 17, 2009
This study compared the effects of undifferentiated and differentiated adipose tissue-derived stromal cells (ADSCs) on functional recovery after spinal cord injury (SCI) in rats. ADSCs were differenti...
KEY FINDING: Transplantation of uADSCs, dADSC-P1, and dADSC-P2 all significantly improved locomotor functional recovery in SCI rats compared to saline-treated controls.