Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,551-11,560 of 12,052 results
J. Comp. Neurol., 2010 • March 23, 2010
This study used lampreys to investigate the regeneration of synapses after spinal cord injury, focusing on the giant reticulospinal (RS) neurons. The key finding was that despite robust functional rec...
KEY FINDING: Regenerated giant RS axons produced very few synapses compared to control axons, particularly within and distal to the lesion scar.
PLoS ONE, 2010 • March 16, 2010
This study demonstrates that RNA aptamers can be selected to bind the Nogo-66 receptor (NgR) and compete with myelin-derived inhibitors of axon regeneration for binding to the receptor. Neurite outgro...
KEY FINDING: RNA aptamers can be generated that bind with high affinity to NgR.
Neuron, 2010 • March 11, 2010
This study demonstrates that miRNAs, particularly miR-219 and miR-338, are critical regulators of oligodendrocyte differentiation and myelination in the vertebrate CNS. The research shows that miRNAs ...
KEY FINDING: Deletion of Dicer1, an enzyme essential for miRNA processing, in oligodendrocyte lineage cells leads to severe myelination deficits in mice.
Neuroscience, 2010 • March 10, 2010
This study investigates the mechanisms underlying the recovery of stepping ability in rats after a complete spinal cord transection (ST) at a neonatal stage. The research focuses on whether this recov...
KEY FINDING: Stepping performance was significantly better in spinal cord transected rats trained on a treadmill compared to non-trained rats, indicating that training enhances locomotor ability after neonatal spinal cord injury.
The Journal of Neuroscience, 2010 • March 10, 2010
This study demonstrates the feasibility of using SEMS to induce locomotor-like movements in non-injured individuals, providing a novel noninvasive approach to access the human locomotor spinal circuit...
KEY FINDING: SEMS at the T11-T12 vertebrae induced involuntary bilateral locomotor-like movements in the legs of individuals.
Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2010 • March 1, 2010
The review discusses the challenges of nerve injuries and the limitations of axon regeneration in the central nervous system (CNS) and peripheral nervous system (PNS). It explores two main strategies ...
KEY FINDING: Nanomaterials can support axon regeneration by providing artificial constructs that replace the inhibitory environment in the CNS and PNS.
J Comp Neurol, 2010 • March 1, 2010
The study investigates the long-term effects of lateral frontal motor cortical injury on the corticospinal projection (CSP) from the supplementary motor cortex (M2). It demonstrates that recovery from...
KEY FINDING: Recovery of dexterous movements from isolated lateral frontal injury is accompanied by selective contralateral terminal axon sprouting and bouton proliferation that is restricted to spinal laminae VII and IX.
JOURNAL OF NEUROTRAUMA, 2010 • March 1, 2010
The study examined molecular changes in the cervical spinal cord of rhesus monkeys after traumatic brain injury (TBI), focusing on long-term effects up to 12 months post-lesion. Key findings include i...
KEY FINDING: There were significant increases in MHC-II and ERK1/2 immunoreactivity in the lateral corticospinal tract (LCST) of the cervical spinal cord up to 12 months post-lesion, indicating long-term microglial activation.
Exp Neurol, 2010 • March 1, 2010
This study examined the origin and distribution of noradrenergic (NA) axons in the spinal cord caudal to a complete transection in adult rats, focusing on the impact of olfactory ensheathing glia (OEG...
KEY FINDING: NA axons are present throughout the caudal stump of both media- and OEG-injected spinal rats, entering the spinal cord from the periphery via dorsal and ventral roots and along large penetrating blood vessels.
J Neurosci Res, 2010 • March 1, 2010
This study investigated the use of x-ray diffraction (XRD) as a rapid method to assess myelin integrity in fixed CNS tissues, aiming to aid research on de- and remyelination in spinal cord injury and ...
KEY FINDING: Fixation introduces variation in myelin periodicity and amount. The range in myelin periodicity (155–190 Å) and the broadened x-ray reflections show fixation-dependent effects.