Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,511-11,520 of 12,052 results
PNAS, 2010 • June 22, 2010
This study investigated the effect of sialidase on recovery from spinal cord contusion injury in rats. Sialidase was delivered intrathecally to the injury site for two weeks, and motor behavior, auton...
KEY FINDING: Sialidase treatment significantly enhanced hindlimb motor function in rats with spinal cord contusion injuries, as measured by the BBB locomotor rating scale.
Neuron, 2010 • June 10, 2010
The study investigates the role of myelin inhibitors Nogo, MAG, and OMgp in axon regeneration and sprouting after spinal cord injury using genetically modified mice. Results indicate that deleting any...
KEY FINDING: Deleting any one of the inhibitors (Nogo, MAG, or OMgp) enhanced sprouting of corticospinal or raphespinal serotonergic axons.
BMC Neuroscience, 2010 • June 4, 2010
The study examines the intrinsic post-axotomy response of thoracic propriospinal (TPS) neurons following spinal cord injury (SCI), focusing on changes in gene expression at different time points. The ...
KEY FINDING: A strong and early upregulation occurs in the expression of genes involved in the immune/inflammatory response that returned towards normal by 1-week post-injury.
J Physiol, 2010 • June 2, 2010
This study investigated the sprouting capacity of lumbar motoneurons in normal and hemisected spinal cords of rats, focusing on the effectiveness of motor unit enlargement in compensating for partial ...
KEY FINDING: Enlargement of intact motor units (MUs) by sprouting was effective in compensating for up to 80% loss of innervation.
Exp Neurol, 2010 • June 1, 2010
This study investigates the role of EphA4 in astroglial-fibrotic scar formation after spinal cord injury (SCI) using EphA4 mutant mice. The results indicate that EphA4 deletion does not significantly ...
KEY FINDING: EphA4 expression is primarily associated with astrocytes in the spinal cord and neurons in the cerebral cortex before and after SCI.
Osteoporos Int., 2010 • June 1, 2010
Surveillance of femur metaphysis bone mineral density (BMD) decline after spinal cord injury (SCI) may be subject to slice placement error of 2.5%. Adaptations to anti-osteoporosis measures should exc...
KEY FINDING: BMD demonstrated a rapid decline over 2 years post-injury.
Neurorehabil Neural Repair, 2010 • June 1, 2010
This study investigated the effect of high-frequency rTMS on lower limb spasticity in patients with incomplete SCI. Patients received either active or sham rTMS over the leg motor area for 5 days. The...
KEY FINDING: High-frequency rTMS over the leg motor area significantly reduced lower limb spasticity in patients with incomplete SCI.
Exp Neurol, 2010 • June 1, 2010
This study examined the effects of PEGylated interferon-β (IFN-β), alone and in combination with forced exercise, on recovery after cervical spinal cord injury (SCI) in rats. The acute biochemical stu...
KEY FINDING: Significant improvements in forelimb function were observed one week post-injury in the group treated with PEGylated IFN-β, but these improvements were not sustained long-term.
Exp Neurol, 2010 • June 1, 2010
This study investigated the use of adaptive neuromuscular electrical stimulation (aNMES) to provide repetitive movement of hip joints in rodents with incomplete thoracic spinal cord injury. The aNMES ...
KEY FINDING: aNMES automatically and reliably tracked the desired hip trajectory with low error during lengthy sessions.
J Neural Eng, 2010 • June 1, 2010
This study demonstrates that humans can learn to use scalp-recorded EEG activity to control three movement dimensions simultaneously and independently. The 3-D control develops through training as the...
KEY FINDING: Humans can learn to use EEG for three-dimensional control.