Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,501-11,510 of 12,052 results
Frontiers in Neuroanatomy, 2010 • July 13, 2010
The study provides a detailed immunohistochemical analysis of PlexinA4 expression in the adult rat CNS, revealing its widespread distribution in neurons and fibers throughout the brain and spinal cord...
KEY FINDING: PlexinA4 is widely expressed throughout the adult rat brain, including the cortex, hippocampus, brainstem, pontine and medullary nuclei.
Frontiers in Neurology, 2010 • July 12, 2010
The current surgical technique for longitudinal spinal cord injury has shown success in restoring some motor function and alleviating pain, but there are still many obstacles. Root avulsion injury res...
KEY FINDING: Surgical replantation of avulsed cervical and lumbosacral ventral spinal roots can promote spinal cord regeneration of autonomic and somatic motoneurons.
Indian J Orthop, 2010 • July 1, 2010
This experimental study investigates the regenerative cell proliferation effects of bone marrow supplemented with neurotransmitters combinations in the regeneration of spinal cord injury The monoplegi...
KEY FINDING: The monoplegia in the test group of rats recovered significantly (P value < 0.01) with supplementation of the bone marrow cells and neurotransmitters combination.
Nat Rev Neurol, 2010 • July 1, 2010
Stem cell therapy holds promise for treating spinal cord injury (SCI) by potentially replacing damaged cells, providing trophic support, and facilitating axon regeneration. While stem cell transplanta...
KEY FINDING: Stem cell transplantation strategies for SCI include replacing lost or damaged cells (neurons and oligodendrocytes), providing trophic support, and manipulating the environment to facilitate axon regeneration.
Spinal Cord, 2010 • July 1, 2010
This systematic review examined the effectiveness of treatments used to prevent and treat heterotopic ossification (HO) in the spinal cord injury (SCI) population. The review found that pharmacologica...
KEY FINDING: NSAIDs, specifically rofecoxib and indomethacin, reduce the incidence of HO when administered early (3 weeks) after SCI, supported by Level 1 evidence.
Exp Neurol, 2010 • July 1, 2010
This study examined the effectiveness of shallow-water walking as a rehabilitation strategy for rats with spinal cord injuries. The researchers found that while shallow-water training improved steppin...
KEY FINDING: Shallow water training improved stepping in shallow water but did not improve overground locomotion in rats with moderately-severe spinal cord injuries.
Disabil Health J, 2010 • July 1, 2010
This review examined studies from 1990-2007 focusing on wellness interventions for individuals with chronic and disabling conditions, aiming to evaluate the evidence supporting these interventions. Th...
KEY FINDING: The number of studies on wellness interventions for people with chronic and disabling conditions increased significantly from 2001-2007.
Journal of NeuroEngineering and Rehabilitation, 2010 • June 23, 2010
This study quantified the effects of a single dose of tizanidine on the neuromuscular abnormalities associated with spasticity, focusing on reflex and intrinsic neuromuscular properties. The findings ...
KEY FINDING: Tizanidine significantly decreased stretch-evoked joint torque at the ankle (p < 0.001).
PLoS Biology, 2010 • June 22, 2010
This present study demonstrates that the intracellular levels of NCS1 in adult cortical neurons can be significantly elevated by transduction with a lentiviral vector. Similarly, analogous experiments...
KEY FINDING: NCS1 overexpression in uninjured corticospinal neurons exhibited axonal sprouting across the midline into the CST-denervated side of the spinal cord following unilateral pyramidotomy.
PNAS, 2010 • June 22, 2010
The study examines the topographic specificity of sensory axon regeneration in the spinal cord following dorsal root crush, using soluble Nogo receptor peptide (sNgR) and artemin (ART) treatments. sNg...
KEY FINDING: Artemin (ART) treatment promotes topographically specific regeneration of sensory axons after dorsal root crush, while soluble Nogo receptor peptide (sNgR) does not.