Assessing spinal axon regeneration and sprouting in Nogo, MAG and OMgp deficient mice

The study investigates the role of myelin-derived inhibitors Nogo, MAG, and OMgp in axon regeneration after spinal cord injury. The researchers created mice lacking these inhibitors to see if their absence would improve axon growth and recovery. The research focused on two types of axonal growth: regeneration of damaged axons and sprouting of undamaged axons. The study examined how the absence of these inhibitors affected these processes. The findings suggest that while these inhibitors may play a role in axon sprouting, they are not the primary reason for the failure of axon regeneration in the central nervous system after injury.

• 1
  Deleting any one of the inhibitors (Nogo, MAG, or OMgp) enhanced sprouting of corticospinal or raphespinal serotonergic axons.
• 2
  There was no synergistic effect of deleting all three inhibitors on axon sprouting, and no associated behavioral improvement was observed.
• 3
  Triple mutant mice lacking all three inhibitors failed to exhibit enhanced regeneration of either axonal tract after spinal cord injury.