Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,441-11,450 of 12,052 results
The Journal of Neuroscience, 2010 • December 1, 2010
The study assessed the impact of soleus (SOL) H-reflex up-conditioning on the recovery of SOL and tibialis anterior (TA) EMG activity and reflexes following sciatic nerve transection and repair in rat...
KEY FINDING: SOL (and probably TA) background EMG activity recovered faster in TU rats than in TC rats.
CELLULAR REPROGRAMMING, 2010 • December 1, 2010
The study introduces a novel animal model for SCI research using cloned Yucatan minipigs, focusing on sacrocaudal spinal cord transection to induce tail paralysis while preserving other motor function...
KEY FINDING: Transection of the sacrocaudal spinal cord in Yucatan minipigs induces quantifiable tail paralysis without causing impairment in pelvic limb, urinary, or bowel functions.
JOURNAL OF NEUROTRAUMA, 2010 • December 1, 2010
This study investigates strategies to rescue injured rat cervical motoneurons following C7 ventral root avulsion. The approaches included reimplantation, nerve grafts, and riluzole treatment, both alo...
KEY FINDING: Avulsion without reimplantation resulted in very low numbers of surviving motoneurons.
Nat Neurosci, 2010 • December 1, 2010
The study demonstrates substantial spontaneous plasticity of corticospinal axons in primates after spinal cord injury, restoring axon density to 60% of normal levels. This axonal regeneration correlat...
KEY FINDING: After a C7 spinal cord hemisection in adult rhesus monkeys, corticospinal projections exhibited remarkable spontaneous plasticity, with reconstitution of approximately 60% of pre-lesion axon density.
American Journal of Pathology, 2010 • December 1, 2010
This study demonstrates that the alternative and terminal complement pathways play key roles in the pathophysiology of spinal cord injury (SCI). Mice deficient in factor B (fB), a component of the alt...
KEY FINDING: Mice deficient in factor B (fB), a protein in the alternative complement pathway, were protected from traumatic SCI, showing reduced tissue damage, demyelination, and inflammatory cell infiltrate.
Exp Brain Res, 2010 • December 1, 2010
This study explores how individuals with and without spinal cord injuries reorganize their upper body movements to control a cursor on a screen, simulating the control of assistive devices. The result...
KEY FINDING: Both SCI and control subjects demonstrated fast body movement reorganization to operate the upper body–cursor interface with smoother, faster and more precise trajectories.
PM R, 2010 • December 1, 2010
LLLT is increasingly used in physical medicine and rehabilitation for wound healing and pain relief, and its applications have expanded to include stroke, myocardial infarction, and brain disorders. T...
KEY FINDING: Transcranial LLLT improved recovery after ischemic stroke in rats.
BMC Neuroscience, 2010 • November 23, 2010
This study examines the intrinsic response of long descending propriospinal tract (LDPT) neurons to axotomy following a low thoracic spinal cord injury (SCI) in rats, comparing their response to short...
KEY FINDING: LDPT neurons exhibit a broad down-regulation of genes related to growth factors and axonal regeneration early after a low thoracic spinal cord injury.
World J Gastroenterol, 2010 • November 21, 2010
This study investigated colonic motility, specifically high amplitude propagating contractions (HAPC), in individuals with spinal cord injury (SCI) compared to healthy controls. The key finding was th...
KEY FINDING: High amplitude propagating contractions (HAPC) were absent in individuals with spinal cord injury (SCI) during pre-sleep, sleep, and post-sleep phases.
Clin Orthop Relat Res, 2011 • November 16, 2010
This systematic review evaluates three treatment strategies for spinal cord injury: riluzole, Rho antagonists (Cethrin), and early surgical decompression. The review addresses specific questions about...
KEY FINDING: Riluzole, a neuroprotective agent, has shown promise in preclinical studies by protecting local tissue and aiding functional neurologic recovery. It is now in human clinical trials.