Surgery Research

KEY FINDING: Seven out of eight patients showed signs of nerve regeneration after allograft transplantation, indicated by return of sensory and motor function or a migrating Tinel’s sign.

KEY FINDING: Damage to the dorsal midline, particularly the spinal cord, affects regenerate morphology up to 24 hours post-amputation.

KEY FINDING: The researchers found that ATP levels, astrogliosis, and microglia activation were reduced in the KO mice lacking Cx43. Furthermore, the researchers assessed functional recovery of the mice by measuring compound action potentials (CAPs). They found that Cx43 KO mice exhibited improved preservation of spinal cord conduction than CX43 WT mice after spinal cord injury.

KEY FINDING: Intramedullary schwannomas can be successfully removed via minimally invasive hemilaminectomy, preserving spinal stability.

KEY FINDING: The described method allows for a reproducible cervical spinal cord laceration injury in mice with an accuracy of ±0.01 mm in lesion depth.

KEY FINDING: Re-implantation of ventral roots significantly increased the survival and regeneration of motoneurons compared to PN graft transplantation.

KEY FINDING: Both ROI-C and CCP groups achieved bony fusion at the final follow-up, indicating similar efficacy in promoting spinal stability.

KEY FINDING: Gabapentin and pregabalin are effective for managing chronic neuropathic pain post-SCI, with pregabalin also potentially reducing anxiety and sleep disturbances. Lamotrigine, valproate, and carbamazepine were found ineffective.

KEY FINDING: Early surgical decompression (within 24 hours of injury) may lead to better neurological outcomes, reduced complications, and shorter hospital stays compared to delayed surgery.

KEY FINDING: CRPS involves a complex interplay of peripheral and central mechanisms, neurogenic and classic inflammation, and potential autoimmune and psychological influences.