Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,791-7,800 of 7,812 results
PLoS ONE, 2010 • July 29, 2010
This study investigates the potential of human motor neuron progenitors (hMNPs), derived from human embryonic stem cells (hESCs), to treat spinal cord injury (SCI) in rats. The research demonstrates t...
KEY FINDING: hMNP transplantation suppresses SCI pathogenesis-related signaling pathways, which correlates with enhanced endogenous neuronal survival and neurite branching.
Nat Neurosci, 2010 • September 1, 2010
This study investigates the role of PTEN/mTOR in controlling the regenerative capacity of mouse corticospinal neurons after spinal cord injury. The researchers found that forced up-regulation of mTOR ...
KEY FINDING: Deleting PTEN in adult corticospinal neurons enhances compensatory sprouting of uninjured CST axons.
Indian J Orthop, 2010 • July 1, 2010
This experimental study investigates the regenerative cell proliferation effects of bone marrow supplemented with neurotransmitters combinations in the regeneration of spinal cord injury The monoplegi...
KEY FINDING: The monoplegia in the test group of rats recovered significantly (P value < 0.01) with supplementation of the bone marrow cells and neurotransmitters combination.
The Journal of Neuroscience, 2010 • August 11, 2010
This study investigates the potential of genetically attenuating myelin and Semaphorin-mediated inhibition to promote axon regeneration after spinal cord injury. The research focused on serotonergic a...
KEY FINDING: Deleting Nogo, MAG, and NgR1 (three myelin inhibitors) did not enhance serotonergic axon regeneration after complete spinal cord transection.
The Journal of Clinical Investigation, 2010 • September 1, 2010
This commentary discusses a study by Abematsu et al. on neural stem cell transplantation in a mouse model of spinal cord injury (SCI). The study demonstrates that transplanted neural stem cells, when ...
KEY FINDING: Neural stem cell transplantation can reconstruct spinal neuronal circuits in mice with severe spinal cord injury.
The Journal of Neuroscience, 2010 • August 25, 2010
This study challenges the long-standing controversy about whether spinal cord injury (SCI) causes retrograde cell death of corticospinal tract (CST) neurons. By directly assessing CST axons in the med...
KEY FINDING: Only a small fraction of axons in the medullary pyramid showed signs of degeneration after SCI, comparable to uninjured rats.
Exp Neurol, 2010 • November 1, 2010
This study investigates the effects of cycling exercise on the expression of apoptosis-associated microRNAs (miRs) after spinal cord injury (SCI) in rats. SCI leads to increased expression of pro-apop...
KEY FINDING: SCI results in increased expression of miR Let-7a and miR16.
J Neurosci Res, 2010 • November 1, 2010
This study demonstrates that injection of IKVAV-PA into the injured spinal cord consistently improves behavioral outcome in both rats and mice with different spinal cord injury models. The major poten...
KEY FINDING: IKVAV PA injection leads to a significantly higher density of serotonergic fibers caudal to the injury site in the chronically injured spinal cord.
Nat Neurosci, 2010 • December 1, 2010
The study demonstrates substantial spontaneous plasticity of corticospinal axons in primates after spinal cord injury, restoring axon density to 60% of normal levels. This axonal regeneration correlat...
KEY FINDING: After a C7 spinal cord hemisection in adult rhesus monkeys, corticospinal projections exhibited remarkable spontaneous plasticity, with reconstitution of approximately 60% of pre-lesion axon density.
Exp Neurol, 2011 • October 1, 2011
This study investigates the effects of RhoA-inhibiting NSAIDs on oligodendrocyte survival and axonal myelination after spinal cord injury (SCI). The findings demonstrate that ibuprofen and indomethaci...
KEY FINDING: Ibuprofen and indomethacin reduced oligodendrocyte cell death in cultures exposed to TNF-α.