Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,781-7,790 of 7,812 results
Brain Res Bull, 2011 • March 10, 2011
The adult mammalian central nervous system (CNS) faces challenges in recovering from neurotrauma and disease due to axon disruption, neuronal death, target denervation, and functional deficits. Constr...
KEY FINDING: Neurotrophins alone can induce regeneration of sensory axons, but they may not terminate in appropriate target regions without additional guidance signals.
PLoS Biology, 2010 • June 22, 2010
This present study demonstrates that the intracellular levels of NCS1 in adult cortical neurons can be significantly elevated by transduction with a lentiviral vector. Similarly, analogous experiments...
KEY FINDING: NCS1 overexpression in uninjured corticospinal neurons exhibited axonal sprouting across the midline into the CST-denervated side of the spinal cord following unilateral pyramidotomy.
Exp Neurol, 2010 • September 1, 2010
This study investigated the use of peripheral nerve grafts (PNG) combined with chondroitinase ABC (ChABC) to promote axon regeneration after incomplete cervical spinal cord injury (SCI) in adult cats....
KEY FINDING: The peripheral nerve grafts survived in most animals, and thousands of myelinated axons were found within each graft.
Molecular Therapy, 2010 • October 1, 2010
The study investigates the role of tenascin-C (TNC) in spinal cord regeneration using TNC-deficient mice and wild-type controls after spinal cord injury. The findings indicate that TNC deficiency impa...
KEY FINDING: TNC-deficient mice exhibit impaired locomotor recovery after spinal cord injury compared to wild-type mice.
PNAS, 2010 • July 13, 2010
This study investigates the therapeutic potential of induced pluripotent stem (iPS) cells for spinal cord injury (SCI) treatment in mice, emphasizing the importance of pre-evaluating iPS cell safety. ...
KEY FINDING: Pre-evaluated safe iPS cells can differentiate into functional neurons, astrocytes, and oligodendrocytes in vitro.
Int J Dev Neurosci, 2010 • October 1, 2010
This study investigates the temporal profile of the P2Y2 nucleotide receptor after spinal cord injury (SCI) in adult female Sprague–Dawley rats, focusing on its role in the pathophysiology response ge...
KEY FINDING: P2Y2 mRNA significantly increased after 2 days post-injury and remained elevated for 28 days.
Cell Mol Neurobiol, 2010 • July 14, 2010
This is a retraction note for an article originally published online on July 14, 2010, in Cellular and Molecular Neurobiology. The reason for the retraction is the duplication of a significant amount ...
KEY FINDING: The original article (DOI 10.1007/s10571-009-9449-4) has been retracted.
TISSUE ENGINEERING: Part A, 2010 • October 1, 2010
This study investigates the effect of astrocyte alignment on neuronal growth using a 3D collagen gel culture system, finding that aligned astrocytes enhance neurite outgrowth. The researchers develope...
KEY FINDING: Astrocyte alignment is significantly greater at the edge and middle of tethered rectangular collagen gels compared to unaligned delta zones.
The Journal of Neuroscience, 2010 • July 21, 2010
The study examined the local and remote neuronal responses to neurotrophic factor-secreting cell grafts placed within sites of right C7 hemisection lesions in the rhesus macaque. Six months after gene...
KEY FINDING: Neurotrophic factors (BDNF and NT-3) administered at the site of spinal cord injury in primates promoted regeneration of axons into the local lesion site.
STEM CELLS, 2010 • July 27, 2010
This study evaluated the therapeutic effects of transplanted hESC-derived oligodendrocyte progenitors (OPC) and/or motoneuron progenitors (MP) on axonal remyelination and functional recovery of adult ...
KEY FINDING: Transplanted OPC and MP survived, migrated, and differentiated into mature oligodendrocytes and neurons within the injured spinal cord.