Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,801-7,810 of 7,812 results
JOURNAL OF NEUROTRAUMA, 2010 • December 1, 2010
This study investigates strategies to rescue injured rat cervical motoneurons following C7 ventral root avulsion. The approaches included reimplantation, nerve grafts, and riluzole treatment, both alo...
KEY FINDING: Avulsion without reimplantation resulted in very low numbers of surviving motoneurons.
Dev Neurobiol, 2011 • July 1, 2011
This study investigates the expression and activation of ephexin after spinal cord injury (SCI) in rats. Ephexin, a guanine nucleotide exchange factor, is involved in Eph signaling pathways that can m...
KEY FINDING: Ephexin protein expression increases after SCI, peaking at 4-7 days post-injury and returning to normal levels by 14 days.
Journal of Biological Chemistry, 2011 • January 21, 2011
This study investigates the role of Paired Immunoglobulin-like Receptor B (PIR-B) in axonal regeneration after spinal cord injury (SCI) using PIR-B-knock-out mice. The researchers found that deleting ...
KEY FINDING: Hindlimb motor function, assessed using various tests, did not significantly differ between PIR-B-knock-out and wild-type mice after dorsal hemisection of the spinal cord.
BMC Neuroscience, 2010 • November 23, 2010
This study examines the intrinsic response of long descending propriospinal tract (LDPT) neurons to axotomy following a low thoracic spinal cord injury (SCI) in rats, comparing their response to short...
KEY FINDING: LDPT neurons exhibit a broad down-regulation of genes related to growth factors and axonal regeneration early after a low thoracic spinal cord injury.
CELLULAR REPROGRAMMING, 2010 • December 1, 2010
The study introduces a novel animal model for SCI research using cloned Yucatan minipigs, focusing on sacrocaudal spinal cord transection to induce tail paralysis while preserving other motor function...
KEY FINDING: Transection of the sacrocaudal spinal cord in Yucatan minipigs induces quantifiable tail paralysis without causing impairment in pelvic limb, urinary, or bowel functions.
Brain, 2011 • April 1, 2011
This study demonstrates that decorin core protein infusion suppresses Sema3A mRNA and protein levels in CNS injury sites, particularly in leptomeningeal fibroblasts within fibrotic scar tissue. Decori...
KEY FINDING: Decorin infusion reduces Sema3A mRNA and protein levels in cerebral cortex scar tissue.
PLoS ONE, 2010 • December 20, 2010
This study aimed to assess the synergistic protective effect of human mesenchymal stem cells (hMSCs) and pituitary adenylate cyclase-activating polypeptide (PACAP) on functional recovery in rats with ...
KEY FINDING: Delayed treatment with PACAP and hMSCs at day 7 post SCI increased the remaining neuronal fibers in the injured spinal cord, leading to better locomotor functional recovery in SCI rats when compared to treatment only with PACAP or hMSCs.
Tissue Engineering: Part A, 2011 • February 2, 2011
The study introduces a method for sustained drug delivery to the transected spinal cord using PLGA microspheres within OPF hydrogels. In vitro and in vivo experiments demonstrated the biological activ...
KEY FINDING: Encapsulating dbcAMP in microspheres prolonged its release and maintained its functionality.
Neural Development, 2011 • January 4, 2011
This study details the cellular and extracellular events during newt spinal cord regeneration after transection injury. It emphasizes the crucial role of meningeal and glial cells in promoting axon re...
KEY FINDING: Axon regeneration following spinal cord transection involves six stages: retraction, growth initiation, wrapping, wisping, spiking, and contact and growth beyond the injury site.
Frontiers in Neurology, 2010 • July 12, 2010
The current surgical technique for longitudinal spinal cord injury has shown success in restoring some motor function and alleviating pain, but there are still many obstacles. Root avulsion injury res...
KEY FINDING: Surgical replantation of avulsed cervical and lumbosacral ventral spinal roots can promote spinal cord regeneration of autonomic and somatic motoneurons.