Effect of neurotransmitters and bone marrow cells for neuronal regeneration in iatrogenic spinal cord injury: An experimental study

Indian J Orthop, 2010 · DOI: 10.4103/0019-5413.65142 · Published: July 1, 2010

Spinal Cord Injury Regenerative Medicine Orthopedics

Simple Explanation

Spinal cord trauma is a major health problem with associated physical, social, economic and psychological sequelae. Despite many advances in research and treatment modalities, the pathophysiology of spinal cord injury remains unclear, and morbidity and mortality among these patients remain high. This experimental study investigates the regenerative cell proliferation effects of bone marrow supplemented with neurotransmitters combinations in the regeneration of spinal cord injury Spinal cord injury model of Wistar rats in the test group were treated by infusing a combination of neurotransmitters and bone marrow at the site of injury using a special polythene tube and reservoir for 21 days.

Study Duration

21 days

Participants

30 Wistar rats with monoplegia

Evidence Level

Not specified

Key Findings

1
The monoplegia in the test group of rats recovered significantly (P value < 0.01) with supplementation of the bone marrow cells and neurotransmitters combination.
2
The reward-seeking locomotor test and sensory recovery test confirmed recovery from spinal cord injury in the test group with significance.
3
The neurotransmitters and bone marrow combination was responsible for functional recovery in the test group of rats with experimental spinal cord injury

Research Summary

This experimental study investigates the regenerative cell proliferation effects of bone marrow supplemented with neurotransmitters combinations in the regeneration of spinal cord injury The monoplegia in the test group of rats recovered significantly (P value < 0.01) with supplementation of the bone marrow cells and neurotransmitters combination. The neurotransmitters and bone marrow combination was responsible for functional recovery in the test group of rats with experimental spinal cord injury We believe that the combination of neurotransmitters along with bone marrow may be a scope of future research in patients with spinal cord injury.

Practical Implications

Future Research

Further research should focus on the neurotransmitters and bone marrow combination for spinal cord injury.

Clinical Trials

Clinical trials should be performed to determine if the treatment strategy can be utilized in patients with chronic spinal cord injury.

Axonal Regeneration

Treatment with neurotransmitters and bone marrow can facilitate functional recovery and axonal regeneration in spinal cord injury.

Study Limitations

1
Small sample size of rats
2
Mortality in both test and control groups
3
The exact mechanism by which neurotransmitters and bone marrow facilitate spinal cord regeneration needs further research.

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