Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 191-200 of 7,812 results
STEM CELLS AND DEVELOPMENT, 2014 • April 1, 2014
This study investigates a tissue-engineered neural scaffold composed of Schwann cells (SCs) and neural stem cells (NSCs) modified to overexpress neurotrophin-3 (NT-3) and its receptor TrkC, respective...
KEY FINDING: The tissue-engineered neural scaffold promotes the formation of myelin-like structures in vitro by NSC-derived myelinating cells and SCs.
The Journal of Neuroscience, 2013 • December 11, 2013
The study establishes a correlation between diminished axon growth potential and histone 4 (H4) hypoacetylation in mature dorsal root ganglion (DRG) neurons. It identifies a transcriptional complex in...
KEY FINDING: Diminished axon growth potential correlates with histone 4 (H4) hypoacetylation in mature DRG neurons.
Front Biol (Beijing), 2013 • August 1, 2013
Brain and spinal cord injuries initiate widespread temporal and spatial neurodegeneration, through both necrotic and programmed cell death mechanisms. Successful treatments rely on prevention or reduc...
KEY FINDING: Downregulating PTEN promotes axon regeneration and neuroprotection following CNS trauma.
Journal of Otolaryngology - Head and Neck Surgery, 2013 • December 19, 2013
The study investigates the combinatorial effect of neural precursor cells (NPCs) and self-assembling peptides (SAPs) on nerve regeneration after spinal cord injury in rats. Results showed that SAP + N...
KEY FINDING: SAP + NPC transplantation significantly improved locomotor score compared to control groups.
J. Cell. Mol. Med., 2014 • February 1, 2014
The study investigates the cytoprotective effects of 17b-estradiol (E2) on human eyelid adipose-derived stem cells (hEASCs) against oxidative stress induced by hydrogen peroxide (H2O2) in vitro and in...
KEY FINDING: E2 protects hEASCs against H2O2-induced cell death in vitro.
JOURNAL OF NEUROTRAUMA, 2014 • May 1, 2014
This study investigates the effects of ChABC treatment on astrogliosis and revascularization after spinal cord injury (SCI) in rats. The researchers injected ChABC intrathecally after a spinal cord he...
KEY FINDING: ChABC treatment effectively cleaves CSPG glycosaminoglycan chains and stimulates axonal remodeling within the injury site, accompanied by an extended period of astrocyte remodeling.
The Journal of Neuroscience, 2014 • January 29, 2014
The study investigates the effects of transplanting Schwann cells (SCs) genetically modified to secrete a bifunctional neurotrophin (D15A) and chondroitinase ABC (ChABC) into a subacute contusion inju...
KEY FINDING: Transplantation of SCs secreting both D15A and ChABC yielded the best responses including the largest number of SC myelinated axons and more propriospinal axons.
STEM CELLS TRANSLATIONAL MEDICINE, 2014 • February 3, 2014
This study assessed the safety and efficacy of transplanting bone marrow nucleated cells (BMNCs) to treat children with complete interruption of spinal cord (SC) continuity. The results indicate that ...
KEY FINDING: BMNC transplantation in children with complete SC injury is safe and feasible.
Spine J., 2014 • September 1, 2014
This pilot study demonstrated that a PLGA scaffold improved regeneration of axons into peripheral nerve roots. The channels in the scaffold served as a mechanical bridge for axons to regenerate betwee...
KEY FINDING: The PLGA scaffold treatment group showed a statistically significant improvement in axon regeneration through the injury compared to the control group.
The Journal of Neuroscience, 2014 • February 12, 2014
This study identifies periostin (POSTN) as a key factor secreted by GDAsBMP astrocytes that promotes axonal regeneration after spinal cord injury (SCI). POSTN expression in GDAsBMP is essential for th...
KEY FINDING: Periostin (POSTN) is identified as a key component of GDABMP-induced axonal regeneration.