Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 181-190 of 7,812 results
BMC Neuroscience, 2013 • September 27, 2013
The study demonstrates that transplanting OEG and SCs in the sub-acute phase after spinal cord injury improves anatomical outcomes. This is achieved by increasing spared/regenerated supraspinal fibers...
KEY FINDING: Both OEG and SCs transplantation increased locomotion in rats with spinal cord injuries, as measured by open field tests.
The Journal of Spinal Cord Medicine, 2014 • January 1, 2014
This study investigated the effect of bridging defects in chronic spinal cord injury using peripheral nerve grafts combined with a chitosan-laminin scaffold and enhancing regeneration through them by ...
KEY FINDING: Motor level improved four levels in 2 cases and two levels in 12 cases.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2013 • July 17, 2013
This study aimed to determine if FK506 and NGF had a synergistic effect on the recovery of spinal cord functions in rats with acute spinal cord injury. The results demonstrated that the combined treat...
KEY FINDING: The combined treatment of FK506 and NGF significantly enhanced the expression of NF200 in rats with spinal cord injury.
PLoS ONE, 2013 • October 11, 2013
This study analyzed gene expression changes in the spinal cord after injury and transplantation of MSCs or OECs. Acute transplantation of MSCs and OECs induced early expression of genes related to cel...
KEY FINDING: MSC and OEC transplanted acutely after injury up-regulate genes related to tissue protection and regeneration.
Cell Transplant, 2015 • January 1, 2015
This study demonstrates that the transplantation of a SC bridge alone promotes brainstem axon regeneration. This study demonstrated that initially fluid bridges promote both a robust increase in the e...
KEY FINDING: Initially fluid bridges of SCs and Matrigel improved regeneration of brainstem axons across the rostral interface compared to pregelled bridges.
The Journal of Neuroscience, 2013 • October 23, 2013
This study investigates the potential of embryonic neural stem cell grafts to restore cardiovascular function after complete spinal cord transection in adult rats. The key finding is that brainstem-de...
KEY FINDING: Grafting brainstem-derived neural stem cells (BS-NSCs) resulted in recovery of basal cardiovascular parameters in rats with complete spinal cord transection.
Tissue Engineering, 2014 • May 1, 2014
This study investigates the long-term effects of implanted multiple channel bridges on axon regeneration and matrix changes in a rat spinal cord injury model. The bridges are designed to provide struc...
KEY FINDING: Axons grew into and through the channels of the implanted bridges, with axon density increasing over time and peaking at 6 months post-implantation, even after the bridge had fully degraded.
Curr Opin Organ Transplant, 2013 • December 1, 2013
Schwann cell transplantation for spinal cord injury is in the early stages of clinical testing, following promising preclinical development. The FDA approved a Phase 1 safety and feasibility study bas...
KEY FINDING: Transplanted Schwann cells have shown reparative effects in the damaged spinal cord, supporting axonal sprouting and myelination.
Nature Communications, 2013 • November 12, 2013
This study investigates the role of chondroitin sulfate N-acetylgalactosaminyltransferase-1 (T1) in spinal cord injury recovery. The research demonstrates that T1 knockout mice exhibit superior recove...
KEY FINDING: T1KO mice exhibit significantly better recovery from spinal cord injury compared to wild-type and ChABC-treated mice, based on locomotor behaviors and histological analysis.
Clinical and Developmental Immunology, 2013 • July 2, 2013
This study compared the astrogliosis and macrophage/microglial cell responses 7 days after either immunological demyelination or a stab injury to the dorsal funiculus of rats. It also examined the ast...
KEY FINDING: Immunological demyelination induces a robust macrophage/microglial cell activation.