Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 201-210 of 7,812 results
PLoS ONE, 2014 • February 11, 2014
This study investigates the expression of guidance and synaptogenic molecules in the cervical spinal cord of mice, both healthy and with spinal cord injuries, focusing on interneuron populations. The ...
KEY FINDING: Most of the guidance and synaptogenic molecules studied are present not only in the developing CNS but also in the adult CNS.
Cell Death and Differentiation, 2014 • February 21, 2014
This study investigates the role of Galectin-1 (Gal-1) in promoting axonal regeneration and functional recovery after spinal cord injury (SCI). The results demonstrate that Gal-1 binds to the NRP-1/Pl...
KEY FINDING: Galectin-1 (Gal-1) promotes full locomotor functional recovery and that an early intervention with this lectin was sufficient to prevent hindlimb loss of function after SCI.
Tissue Engineering, 2014 • March 19, 2014
Substantial progress has been made in improving nerve function in SCI patients through nerve tissue regeneration. This perspective provides an overview of SCI research and tissue-engineered nerve rege...
KEY FINDING: Progress has been made in using cell therapy, including embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs), for nerve regeneration in SCI patients.
Nat Commun., 2014 • January 1, 2014
This study demonstrates that resident astrocytes in the injured adult spinal cord can be manipulated to produce neurons by defined factors, raising the possibility of using these cells as a source for...
KEY FINDING: Ectopic SOX2 expression is sufficient to convert endogenous spinal astrocytes to proliferative DCX-positive neuroblasts in the injured adult spinal cord.
Neurosci Lett, 2014 • June 24, 2014
This study investigates the neuroprotective effects of bisperoxovanadium (bpV), a PTEN inhibitor, in a rat model of cervical spinal cord injury (SCI). The researchers hypothesized that bpV could incre...
KEY FINDING: bpV treatment promoted significant spared white matter (30%; p < 0.01).
Neurosurgery, 2014 • July 1, 2014
This study investigates the role of NgR1 in limiting axon regeneration after spinal cord injury (SCI). Using mice with varying degrees of NgR1 deficiency and SCI severity, the research aimed to clarif...
KEY FINDING: The level of functional recovery is affected by the degree of injury suffered, with NgR1 ablation leading to significant recovery in locomotor function following severe SCI.
The Journal of Neuroscience, 2014 • March 5, 2014
This study investigates the distribution of VGLUT1 synapses on motoneurons before and after peripheral nerve injury and regeneration in rats. The researchers mapped the location of these synapses alon...
KEY FINDING: In healthy motoneurons, VGLUT1 synapses are mainly located on proximal dendrites, grouped in tight clusters.
Curr Opin Neurobiol, 2014 • August 1, 2014
The Nogo-A and NgR1 signalling cascade have been studied extensively with regard to neurological trauma. Blockade of these pathways leads to greater functional recovery through a combination of neural...
KEY FINDING: Targeting the Nogo-A/NgR1 pathway has demonstrated effectiveness in promoting functional recovery and neural repair following various CNS injuries, including spinal cord trauma, stroke, and optic nerve damage.
PLoS ONE, 2014 • March 25, 2014
This study investigates the regulation of Interleukin-6 (IL-6) secretion by astrocytes after spinal cord injury (SCI). It identifies the PI3K-mTOR-Calcium signaling pathway as a key regulator of IL-6 ...
KEY FINDING: IL-6 is expressed by astrocytes, neurons, and microglia/macrophages in the spinal cord after contusion injury.
PLoS ONE, 2014 • March 25, 2014
This study evaluated the neuroprotective and neuroregenerative properties of NX210, a peptide derived from SCO-spondin, in vitro and in vivo for the treatment of spinal cord injury (SCI). In vitro stu...
KEY FINDING: NX210 provides neuroprotection against oxidative stress in B104 neuroblastoma cells in vitro.