Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 691-700 of 702 results
J Transl Med, 2019 • December 20, 2019
The study systematically compares pooled HPL-based medium preparations (pHPL) and two differentially fibrinogen-depleted variants and FBS with respect to biochemical composition. Cell proliferation wa...
KEY FINDING: pHPL-supplemented media supported proliferation of WAT- and UC-derived stromal cells significantly better than FBS.
Neural Regen Res, 2020 • January 28, 2020
This study protocol outlines a clinical trial to investigate the use of human umbilical cord mesenchymal stem cells (hUC-MSCs) for treating spinal cord injury (SCI) in the early chronic phase. The tri...
KEY FINDING: The primary goal is to see if hUC-MSCs can improve the ASIA (American Spinal Injury Association) total score in patients with early chronic SCI.
Brain, 2020 • May 6, 2020
This study investigated the safety and efficacy of NgR1-Fc (AXER-204), a Nogo receptor decoy, in treating spinal cord injury in non-human primates. The results indicated that NgR1-Fc is safe for admin...
KEY FINDING: NgR1-Fc (AXER-204) administration showed no preclinical toxicological issues in healthy animals or safety concerns in spinal cord injury animals.
Ann Transl Med, 2020 • March 1, 2020
The study established a mouse model of SCI involving a crush injury followed by scar removal to simulate clinical treatment of SCI. The model was validated using BMS scoring, electrophysiology, and hi...
KEY FINDING: The initial crush injury model resulted in significant neurological deficits with limited natural recovery, as evidenced by behavioral scoring and electrophysiology.
COMMUNICATIONS BIOLOGY, 2020 • June 12, 2020
This approach revealed that the M-axon can regenerate very rapidly and that essential functions of the behavior driven by this neuron are fully recovered in just days. As we report here, the regenerat...
KEY FINDING: Mauthner (M-) axon might regenerate better when the spinal cord is injured closer to the soma of the M-cell.
Frontiers in Endocrinology, 2020 • July 17, 2020
This review highlights the potential of zebrafish as a model for personalized regenerative medicine, particularly in the context of endocrine diseases. Zebrafish possess remarkable regenerative capabi...
KEY FINDING: Zebrafish possess regenerative capabilities in various organs, making them suitable for studying regenerative medicine approaches for endocrine disorders like diabetes mellitus.
J Extracell Vesicles, 2020 • October 26, 2020
The development of EV therapeutics hinges on the ability to consistently produce EVs with reliable therapeutic efficacy, necessitating well-standardized assays. Functional assays, which evaluate the e...
KEY FINDING: Functional assays are crucial for assessing the molecular and physiological effects of EV preparations on target cells, organoids, organs, or organisms.
Bio-protocol, 2017 • June 20, 2017
This study outlines a detailed protocol for establishing a contusion spinal cord injury (SCI) model in adult rats, utilizing the NYU-MASCIS weight-drop impactor. The method aims to replicate the commo...
KEY FINDING: The study details the surgical procedure for creating a reproducible contusion SCI model in rats using the NYU-MASCIS impactor.
Cytotechnology, 2006 • December 5, 2006
This study introduces an optimized method for preparing highly pure astrocyte cultures from rat spinal cord. The method involves modifications to the isolation procedures and cultivation conditions, i...
KEY FINDING: The optimized method consistently produced astrocyte cultures with greater than 99% purity, as confirmed by immunofluorescence staining against GFAP and OX-42.
Drug Discov Today Dis Models, 2007 • January 1, 2007
Mammals have a limited capacity for heart regeneration, unlike zebrafish. Zebrafish can regenerate heart tissue after injury, making them a valuable model for studying cardiac regeneration. Zebrafish ...
KEY FINDING: Zebrafish heart muscle can regenerate after injury with minimal scarring, replacing lost tissue with new contractile muscle.