Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 671-680 of 702 results
STEM CELLS TRANSLATIONAL MEDICINE, 2017 • July 17, 2017
The review addresses the growing interest in EVs as therapeutic entities, particularly in stem cell-related approaches, and the need for standardization and coordination of development efforts. It out...
KEY FINDING: EVs, especially from mesenchymal stem cells (MSCs), have therapeutic properties for wound healing, inflammation, cardiovascular disease, brain injury, and cancers.
F1000Research, 2017 • June 15, 2017
The study establishes the tammar wallaby as a bipedal model for spinal cord injury research, highlighting a 'permissive' period for regeneration in early development. Data indicate that regrowth of su...
KEY FINDING: Tammars injured up to 3 weeks of age showed axon regrowth across the spinal cord lesion site, restoring supraspinal innervation.
Neural Regeneration Research, 2017 • August 1, 2017
This study introduces a novel mouse model for chronic progressive spinal cord compression, achieved through gradual tightening of a screw implanted in the spine. The model allows for the assessment of...
KEY FINDING: Hindlimb function worsened progressively with increasing spinal cord compression.
JOURNAL OF NEUROTRAUMA, 2018 • May 1, 2018
The SPRING trial is a phase 2b/3 study evaluating VX-210's efficacy and safety in acute traumatic cervical SCI patients. It aims to determine if VX-210 can augment motor recovery. The primary outcome ...
KEY FINDING: VX-210 inhibits Rho, an enzyme activated post-SCI that prevents nerve regeneration.
F1000Research, 2017 • October 30, 2017
This review highlights the most promising neuroprotective and neural reparative therapeutic strategies undergoing clinical assessment, including riluzole, hypothermia, granulocyte colony-stimulating f...
KEY FINDING: Early surgical decompression, which aims to realign the spinal column and relieve bony or ligamentous spinal cord compression, has preclinical and clinical success.
Front. Neural Circuits, 2017 • November 6, 2017
Finding a treatment for spinal cord injury (SCI) focuses on reconnecting the spinal cord by promoting regeneration across the lesion site. However, while regeneration is necessary for recovery, on its...
KEY FINDING: Synaptic inputs from individual regenerated axons also matched the properties in unlesioned animals, although this was associated with changes in release parameters.
Cell Tissue Res, 2018 • January 1, 2018
Neural stem cells (NSCs) are the stem cells of the nervous system. During development they give rise to the entire nervous system. Because NSCs are regulated by both intrinsic genetic and epigenetic p...
KEY FINDING: During development, the central nervous system (CNS) is generated from a small number of neural stem cells (NSCs) lining the neural tube.
Acta Neurochirurgica, 2018 • January 12, 2018
This study introduces a new, minimal invasive, CT-guided spinal cord injury procedure for minipigs, using a balloon catheter to compress the spinal cord. The procedure was standardized and resulted in...
KEY FINDING: The CT-guided balloon compression technique successfully induced complete spinal cord injuries in minipigs.
Journal of Visualized Experiments, 2018 • January 30, 2018
This article describes a surgical and measurement protocol for assessing lower urinary tract function in awake rats, using implanted catheters and electrodes to simultaneously monitor the urinary blad...
KEY FINDING: The success rate for the surgical procedure and maintaining the implanted devices intact is approximately 80%.
J Spine Surg, 2018 • June 1, 2018
This case report describes a rare complication of total lumbar disc replacement (TDR), where the viscoelastic nucleus of the artificial disc herniated, causing nerve compression and radiculopathy. The...
KEY FINDING: The case report presents an unreported complication of lumbar TDR involving herniation of the viscoelastic nucleus, mimicking a disc herniation.