Regenerative Medicine Research

KEY FINDING: The study demonstrates that type A pericytes are the primary source of scar-forming fibroblasts across various CNS lesions in mice, including spinal cord injury, traumatic brain injury, ischemic stroke, and multiple sclerosis.

KEY FINDING: The developed hydrogel exhibits outstanding electrical conductance upon ES, with continuous release of NGF for at least 24 days.

KEY FINDING: Sparse GAP-43 positive axons are present in the proximal stump of the spinal cord but their number decreased in the bridge at 11–34 days post-transection.

KEY FINDING: Tuatara tail regeneration is a slow process that combines regeneration and growth (“regengrow”), resulting in tails with a cartilaginous axis, connective tissue, fat cells, and sparse nerves.

KEY FINDING: Restoration of functions that are lost following dorsal root injury requires that injured dorsal root axons are able to extend axons through a non-permissive environment, which is rapidly building up at the DREZ.

KEY FINDING: iPSC-based disease models have been studied for cardiac channelopathies including hereditary long QT syndrome (LQTS), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC).

KEY FINDING: Each cell type in the DRG microenvironment responds differently to peripheral (sciatic nerve crush), dorsal root crush, and spinal cord injuries.

KEY FINDING: The iPN hydrogels thermally gel when exposed to 37°C in under 20 minutes and have mechanical properties similar to neural tissue.

KEY FINDING: Stem cells, viral vectors, and biomaterials have shown promise in delivering NTFs to the CNS.

KEY FINDING: Embryonic NSCs transplanted into adult ETs lose roof plate identity and are ventralized by the unchecked Hedgehog signaling of adult lizard tail environments.