BioMed Research International, 2013 · DOI: http://dx.doi.org/10.1155/2013/573169 · Published: October 7, 2013
Peripheral nerve injuries can lead to significant functional loss, and current treatments often have limited success. Researchers are exploring cell transplantation to improve nerve regeneration. This study investigates whether intravenous infusion of mesenchymal stromal cells (MSCs) can enhance recovery in a rat model of peripheral nerve injury. The study found that intravenously injected MSCs reach the site of nerve injury and promote nerve regeneration. Rats treated with MSCs showed improved functional outcomes compared to control groups. The results suggest that cell transplantation using MSCs could be a promising approach to improve functional recovery after peripheral nerve injuries.
Intravenous MSC transplantation could be a potential adjunct therapy to improve functional outcomes after peripheral nerve repair.
Further research is needed to elucidate the precise mechanisms by which MSCs enhance nerve regeneration, including immunomodulation, neovascularization, and neurotrophic influences.
Given the demonstrated safety of intravenous MSC infusion in clinical studies, this approach warrants consideration for clinical translation in nerve defect repairs.