Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 861-870 of 2,298 results
Arch Med Sci, 2012 • June 1, 2012
This study investigated the effect of Schwann cells-alginic acid sodium hydrogel co-transplantation on spinal cord injury in rats. The co-transplantation approach promoted locomotor function recovery,...
KEY FINDING: Schwann cells-alginic acid sodium hydrogel co-transplantation could inhibit cellular apoptosis and enhance Bcl-2 expression in the spinal cord-transected segments.
Neurosci Bull, 2013 • February 1, 2013
Spinal cord injury (SCI) can have a range of debilitating effects and permanently alter the capabilities and quality of life of survivors. In this review, we focus on research progress on the molecula...
KEY FINDING: Normally, the primary injury of the spinal cord is due to either contusion or compression.
Ann N Y Acad Sci, 2013 • April 1, 2013
Several thousand axons regenerate into PNGs yet only 10–15% of these appear to exit the graft when inhibitory proteoglycans in the spinal cord are digested prior to apposition of the distal graft end....
KEY FINDING: Peripheral nerve grafts (PNGs) can effectively bridge spinal cord lesions and promote axon regeneration. The target site can be treated to make it either more attractive or less inhibitory for the extension of axons beyond the distal end of the PNG.
J Rehabil Res Dev, 2013 • June 1, 2013
Regenerative rehabilitation integrates regenerative medicine and rehabilitation to restore function through tissue regeneration and repair. The symposium addressed neurological applications, including...
KEY FINDING: The number of articles on regenerative rehabilitation has increased substantially, particularly between 2010 and 2012.
Nanoscale, 2013 • October 7, 2013
Spinal cord injury (SCI) presents a complex medical challenge due to the limited regenerative capacity of the central nervous system and the difficulty in delivering therapeutic agents effectively. N...
KEY FINDING: Nanomaterials can enhance drug bioavailability through targeted delivery and extended circulation, effectively crossing the blood-spinal cord barrier (BSCB) and cell membranes.
Stem Cells International, 2013 • July 24, 2013
This review discusses recent advances in exogenous MSC therapy for TSCI and vertebral fracture repair, highlighting existing challenges in translational applications. The paper introduces a novel muri...
KEY FINDING: MSCs have the potential to enhance osteogenesis and chondrogenesis for spinal fusion repair, differentiating into osteoblasts with specific bioactive factors.
PLoS ONE, 2013 • September 11, 2013
The study examined the effects of BMSC infusion into the CSF on subacute and chronic SCI in rats. BMSCs were injected into the fourth ventricle of rats at 1, 2, and 4 weeks post-injury, and locomotor ...
KEY FINDING: BMSC transplantation significantly improved locomotor function in both subacute and chronic SCI rats, as measured by the BBB score.
Int. J. Mol. Sci., 2022 • November 2, 2022
The study investigates the gene activation profile of the stressed holothurian CNS using RNA sequencing to compare transected and enzyme-dissected RNC explants with cultured explants. The research ide...
KEY FINDING: Several stress-associated genes, including heat-shock proteins and ubiquitin-related pathways, are differentially expressed in the holothurian CNS following transection and enzyme dissection.
Biomaterials, 2014 • February 1, 2014
This study investigates the effects of ESHU on BMSC transplant survival and repair using a rat model of spinal cord contusion. Transplantation of BMSCs in ESHU at three days post-contusion resulted in...
KEY FINDING: Transplantation of BMSCs in ESHU resulted in a 3.5-fold increase in BMSC survival at one week post-injury.
Journal of Translational Medicine, 2013 • December 20, 2013
The study compared CT-guided stem cell transplantation with open surgical transplantation for treating spinal cord injury sequelae, finding CT-guided transplantation to be safer and more effective. Cl...
KEY FINDING: CT-guided stem cell transplantation resulted in better clinical outcomes compared to open surgical transplantation and the control group.