Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis

Mol Brain, 2021 · DOI: https://doi.org/10.1186/s13041-021-00787-6 · Published: April 30, 2021

Simple Explanation

Amyotrophic lateral sclerosis (ALS) is a fatal disease where motor neurons degenerate. The study investigates if repeated infusions of mesenchymal stem cells (MSCs) can improve outcomes in an ALS rat model, compared to a single infusion. The researchers found that repeated MSC infusions (four times weekly) extended the survival period, protected motor functions, and reduced deterioration of locomotor activity compared to a single infusion or vehicle infusion. The study also showed that rats receiving repeated MSC infusions maintained their ability to walk for a longer period compared to those receiving a single infusion or vehicle.

Study Duration

Not specified

Participants

SOD1G93A transgenic ALS rat model (n=6/group)

Evidence Level

Not specified

Key Findings

1
Repeated infusions of MSCs significantly extended the lifespan of the ALS rat model compared to a single infusion or vehicle control.
2
Rats receiving repeated MSC infusions showed reduced deterioration of motor deficits, as indicated by higher BBB scores over time.
3
Repeated MSC infusions prolonged the period during which rats maintained their gait ability and also helped maintain body weight.

Research Summary

This study investigates the effects of repeated mesenchymal stem cell (MSC) infusions on the SOD1G93A transgenic ALS rat model, comparing it to single infusions and vehicle infusions. The results indicate that repeated MSC infusions significantly extend lifespan, reduce motor function deterioration, and prolong gait ability compared to single infusions. The authors suggest that repeated MSC infusions may offer a promising therapeutic option for ALS, warranting further exploration of the underlying mechanisms.

Practical Implications

Therapeutic Potential for ALS

Repeated MSC infusions could represent a more effective therapeutic strategy for ALS than single infusions.

Improved Quality of Life

The extended period of preserved motor function and gait ability suggests the potential for improved quality of life for ALS patients.

Further Research Needed

Future studies should focus on elucidating the mechanisms underlying the beneficial effects of repeated MSC infusions.

Study Limitations

1
The therapeutic mechanisms of these changes are not elucidated in the current study.
2
The study was conducted on a rat model, and the results may not directly translate to human ALS patients.
3
Further research is needed to optimize the dosage and frequency of MSC infusions.

Your Feedback

Was this summary helpful?

Back to Regenerative Medicine