Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era

Cell-based restorative treatment has become a new trend, and increasing data worldwide have strongly proven that it has a pivotal therapeutic value in CNS disease. Functional neurorestoration has been achieved to a certain extent in the CNS clinically. Based on the complexity of the processes of demyelination and remyelination, degeneration and regeneration, damage and repair, functional loss and recovery, it would be expected that effective therapeutic approaches will require a combination of strategies encompassing neuroplasticity, immunomodulation, neuroprotection, neurorepair, neuroreplacement, and neuromodulation.

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  The emergence of the term “neurorestoratology,” however, signals the birth of a new discipline, which is equally important in comparison with neurology and neurosurgery
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  Generally, the patient’s functional restoration originated from some or all of the mechanisms as listed above.
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  Now people are more interested in and pay more attention to functional neurorestoration rather than the anatomical structure repair of the CNS.