Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 791-800 of 2,298 results
The Journal of Neuroscience, 2007 • October 31, 2007
This symposium summarizes scientific bases for current clinical trials aimed at improving functions after SCI. After primary and secondary damage, endogenous processes may foster or hinder axonal reco...
KEY FINDING: Function-blocking antibodies recognizing Nogo-A induce enhanced regenerative sprouting from injured fibers, long-distance regeneration of subpopulations of fibers, and enhanced compensatory fiber growth from non-injured fibers and tracts.
CNS Neurosci Ther., 2017 • May 29, 2017
This study investigates the use of polyethylene glycol (PEG) to treat spinal paralysis in rats with complete spinal cord transections. Rats treated with PEG showed significant motor recovery compared ...
KEY FINDING: PEG treatment led to recovered ambulation in rats with complete spinal cord transection, as measured by BBB scores.
Neural Regeneration Research, 2017 • May 1, 2017
This meta-analysis evaluated the effectiveness and safety of stem cell transplantation for spinal cord injury (SCI) by analyzing data from ten randomized controlled trials. The findings suggest that s...
KEY FINDING: Stem cell transplantation significantly increased lower limb light touch and pinprick scores compared to rehabilitation therapy.
Exp Neurol, 2008 • June 1, 2008
This study investigates the effect of human adult bone marrow-derived somatic cells (hABM-SC) on stroke recovery in rats. hABM-SC treatment led to improved forelimb function on a skilled motor task, i...
KEY FINDING: hABM-SC therapy after stroke in rats led to significant functional recovery in a skilled forelimb task.
Brain, 2008 • August 8, 2008
This clinical trial evaluated the safety and feasibility of autologous olfactory ensheathing cell (OEC) transplantation in patients with complete thoracic paraplegia. The study followed six transplant...
KEY FINDING: The transplantation of autologous olfactory ensheathing cells into the injured spinal cord was found to be feasible and safe for up to 3 years post-implantation.
BMC Neuroscience, 2009 • April 20, 2009
This study aimed to evaluate the effect of electro-acupuncture (EA) on the survival and differentiation of bone marrow mesenchymal stem cell (MSC) transplantation, axonal regeneration, and functional ...
KEY FINDING: The combination of MSC transplantation and EA treatment significantly increased cAMP and NT-3 levels in the injured spinal cord compared to MSC transplantation or EA treatment alone.
Exp Neurol, 2010 • April 1, 2010
This study investigated the impact of functional electrical stimulation (FES) on cell regeneration in rats with spinal cord injuries (SCI). The research found that FES significantly increased cell bir...
KEY FINDING: FES significantly increased cell birth in the lumbar spinal cord of rats with spinal cord injuries, with an 82-86% increase observed in the injured ‘cell birth’ subgroup.
Neurorehabil Neural Repair, 2010 • January 1, 2010
The article discusses the importance of rehabilitation in conjunction with cellular transplantation for spinal cord injury (SCI). It highlights a study by Lima et al., which combined cell transplantat...
KEY FINDING: 75% of subjects developed electromyographic activity below their lesions.
BMC Neuroscience, 2010 • September 16, 2010
The study investigated the effects of hMSC transplantation on neurogenic bladder and locomotor function recovery in rats with spinal cord injury, also examining the relationship with endogenous neurot...
KEY FINDING: hMSC transplantation reduced ED1 positive macrophages (inflammatory response) in the injured spinal cord compared to control groups.
Cell Mol Neurobiol, 2011 • December 14, 2010
The study investigated the optimal location and timing for neural stem cell (NSC) transplantation in rats with transected spinal cords to improve neurological function. NSC transplantation into spinal...
KEY FINDING: NSC transplantation in the spinal cords rostral to the transection site at the subacute stage (7 days post operation) resulted in significant improvement in hindlimb locomotor functions.