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  4. A case report on the use of sustained release platelet-rich plasma for the treatment of chronic pressure ulcers

A case report on the use of sustained release platelet-rich plasma for the treatment of chronic pressure ulcers

The Journal of Spinal Cord Medicine, 2011 · DOI: 10.1179/107902610X12923394765616 · Published: January 1, 2011

Spinal Cord InjuryRegenerative MedicineDermatology

Simple Explanation

Chronic pressure ulcers are a significant problem for patients, especially those with spinal cord injuries. These wounds can be difficult to heal due to chronic inflammation and aging cells in the affected area. Platelet-rich plasma (PRP) therapy is a potential treatment option that uses a patient's own blood platelets to release growth factors and reduce inflammation, potentially stimulating wound healing. This case report explores the use of a sustained-release PRP method, delivering growth factors over a longer period, to improve healing rates in chronic pressure ulcers compared to traditional methods.

Study Duration
18 weeks
Participants
Three veterans with spinal cord injury
Evidence Level
Level 4: Case Report

Key Findings

  • 1
    PRP treatment consistently resulted in the formation of granulation tissue, which is essential for wound healing.
  • 2
    The PRP treatment also improved vascularity in the treated ulcers, indicating better blood supply to the wound area.
  • 3
    The overall ulcer area and volume were reduced in all three patients treated with sustained release PRP therapy.

Research Summary

This case report investigates the use of sustained release platelet-rich plasma (PRP) therapy for treating chronic stage IV pressure ulcers in three veterans with spinal cord injuries. The PRP treatment involved injecting activated PRP into the wound margins and packing the wound with alginate beads containing PRP for sustained growth factor release. The results showed improved granulation tissue formation, increased vascularity, and reduced ulcer area and volume in all three patients, suggesting a positive effect of PRP on healing rates.

Practical Implications

Potential Treatment for Chronic Ulcers

Sustained release PRP therapy may offer a viable treatment option for chronic pressure ulcers, especially in patients with spinal cord injuries, where conventional treatments have failed.

Improved Wound Healing

The study suggests that PRP can stimulate wound healing by promoting granulation tissue formation and vascularity, potentially leading to faster closure of chronic ulcers.

Reduced Hospitalization

Successful PRP treatment may reduce the need for lengthy hospitalizations and improve the quality of life for patients with chronic pressure ulcers.

Study Limitations

  • 1
    Small sample size (three patients)
  • 2
    Lack of a control group
  • 3
    Undermining ulcers responded slower than non-undermined

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