Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 741-750 of 2,298 results
Brazilian Journal of Medical and Biological Research, 2016 • September 1, 2016
The study investigated the effectiveness of stem cells from human exfoliated deciduous teeth (SHEDs) transplantation combined with treadmill training in rats with experimental spinal cord injury (SCI)...
KEY FINDING: SHEDs treatment alone or in combination with treadmill training promoted functional recovery, with BBB scores significantly higher than the SCI group.
Neural Regeneration Research, 2014 • December 1, 2014
Previous experimental studies have shown that cerebral infarction can be effectively reduced following treatment with scutellaria baicalensis stem-leaf total flavonoid (SSTF). Experimental findings in...
KEY FINDING: Pretreatment with SSTF effectively improved neurological function, reduced brain water content and the permeability of blood vessels.
Scientific Reports, 2016 • September 27, 2016
This study investigates the role of HB-GAM in reversing the inhibitory effects of the CNS extracellular matrix on neural regeneration. It demonstrates that HB-GAM promotes neurite outgrowth by interac...
KEY FINDING: HB-GAM promotes neurite outgrowth on CSPG substrates, overcoming the inhibitory effects of aggrecan, neurocan, and brain-derived CSPGs.
Scientific Reports, 2015 • March 16, 2015
This study investigated whether electroacupuncture (EA) treatment could enhance grafted TrkC-MSCs to differentiate into oligodendrocytes, remyelination and functional recovery in a rat model of demyel...
KEY FINDING: TrkC-MSCs combined with EA significantly increased the number of OPCs and oligodendrocyte-like cells differentiated from MSCs.
Neural Regeneration Research, 2015 • January 1, 2015
This study compares the efficacy of electroacupuncture at local meridian acupoints alone with acupuncture at Governor vessel and local meridian acupoints combined for treating peripheral nerve injury....
KEY FINDING: Acupuncture at Governor vessel and local meridian acupoints combined (GV/LM) showed better clinical response (80%) compared to acupuncture at local meridian acupoints alone (LM) (38.5%).
Clin Trans Med, 2016 • September 21, 2016
The study examines the role of physiotherapy in improving mobilization in patients with spinal cord injury (SCI) who are also undergoing human embryonic stem cell (hESC) therapy. The research indicate...
KEY FINDING: Patients with AIS score A showed improvement to score B (15%) and C (37.3%) after hESC therapy and physiotherapy.
Korean J Neurotrauma, 2016 • August 1, 2016
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit, social, and financial burdens. Over the past decades, various treatments including medication, su...
KEY FINDING: Direct intramedullary injection to the injured spinal cord site in subacute phase is most effective.
J. Clin. Med., 2015 • December 29, 2014
Spinal cord injury (SCI) is a devastating trauma causing long-lasting disability. The use of cell transplantation as a therapeutic strategy for the treatment of SCI is promising, particularly since it...
KEY FINDING: iPSC-derived cells can be useful in the treatment of SCI through cell replacement and restoration of lost myelin and through trophic support, which results in the induction of neuroprotection and a reduction in cell loss.
Stem Cells International, 2015 • February 5, 2015
This review highlights the progress in cell therapy for spinal cord injury (SCI) treatment, focusing on various cell types like pluripotent stem cells, mesenchymal stromal cells (MSCs), and neural ste...
KEY FINDING: Cell transplantation can enhance neuronal regeneration after spinal cord injury by secreting paracrine factors, acting as a scaffold for axonal regrowth, and replacing lost neurons or neural progenitor cells.
Stem Cell Res, 2015 • September 1, 2015
The study quantitatively evaluated the effect of transplantation dose on the spatiotemporal dynamics of human neural stem cell engraftment in the injured central nervous system. The findings suggest t...
KEY FINDING: Transplant dose was inversely correlated with measures of donor cell proliferation at 2 weeks post-transplant (WPT) and dose-normalized engraftment at 16 WPT.