Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 731-740 of 2,298 results
Integr Biol (Camb), 2014 • July 24, 2014
This study investigates the potential of NT3 and SHH, delivered via biomaterial bridges, to enhance axon regeneration and myelination following spinal cord injury (SCI) in mice. The results demonstrat...
KEY FINDING: Sustained expression of NT3 and SHH significantly increased the growth of regenerating axons into the implanted bridge and enhanced their myelination after eight weeks.
BMC Neuroscience, 2014 • July 2, 2014
This study examined the effects of lithium on spinal motoneuron regeneration following ventral root avulsion and reimplantation in rats. The findings suggest that lithium enhances the regenerative cap...
KEY FINDING: Lithium plus reimplantation therapy significantly improved the grasping strength of the injured forepaw.
PLoS ONE, 2014 • August 26, 2014
The study investigates the temporal relationship between swimming ability and regenerated cerebrospinal axon number in adult zebrafish with a complete spinal cord transection. Swimming ability gradual...
KEY FINDING: Swimming ability in zebrafish gradually improves between two and eight weeks after a spinal cord transection, reaching 44% of sham-injured fish.
Journal of Translational Medicine, 2014 • September 2, 2014
This study evaluated the efficacy of umbilical cord mesenchymal stem cell (UCMSC) transplantation for treating sequelae of thoracolumbar spinal cord injury, comparing it to rehabilitation therapy and ...
KEY FINDING: UCMSC transplantation significantly improved motor function in patients with spinal cord injury sequelae.
Top Spinal Cord Inj Rehabil, 2012 • January 1, 2012
This pilot study explored the efficacy and safety of PRP injections for biceps tendinopathy in individuals with spinal cord injury. The study found significant improvements in pain and shoulder functi...
KEY FINDING: The study demonstrated a significant change in the noninjected shoulder on USPRS score, in PESS score, and in the VAS-pain score.
Journal of Biological Chemistry, 2014 • November 21, 2014
This study investigates the therapeutic potential of induced neural stem cells (iNSCs) for spinal cord injury (SCI) in a rat model. The findings demonstrate that engrafted iNSCs can differentiate into...
KEY FINDING: Engrafted iNSCs can differentiate into all neuronal lineages, including different subtypes of mature neurons, and form synapses with host neurons.
Journal of Visualized Experiments, 2014 • October 14, 2014
The study presents a detailed protocol for performing complete spinal cord transections in larval sea lampreys and subsequent brain dissection for wholemount in situ hybridization. The protocol includ...
KEY FINDING: The protocol demonstrates a reliable method for complete spinal cord transection in larval sea lampreys.
Neural Regeneration Research, 2014 • October 1, 2014
This study investigated the synergistic effects of olomoucine and GDAsBMP in treating spinal cord injury in rats. A rat model of acute spinal cord contusion was established, and the treatments were ad...
KEY FINDING: Olomoucine effectively inhibited astrocyte proliferation and the formation of scar tissue at the injury site, but did not prevent proliferation of GDAsBMP or inhibit their effects in reducing the spinal cord lesion cavity.
Scientific Reports, 2016 • August 3, 2016
This study demonstrates that combined therapy with NS/PC transplantation and treadmill training promotes functional recovery in chronic SCI animal models. NS/PC transplantation enhances electrophysiol...
KEY FINDING: The combination of NS/PC transplantation and treadmill training resulted in significant locomotor recovery compared to the control group in mice with chronic SCI.
Nature, 2015 • February 19, 2015
This study investigates the role of PTPσ in inhibiting nerve regeneration after spinal cord injury (SCI). A peptide mimetic (ISP) targeting PTPσ was developed and tested for its ability to promote rec...
KEY FINDING: PTPσ stabilizes growth cones within CSPG-rich substrates, contributing to axonal dystrophy.