Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 751-760 of 2,298 results
Neurobiol Dis, 2017 • February 1, 2017
This study investigates the role of RhoA in axon regeneration and neuronal death after spinal cord injury (SCI) using a lamprey model, which allows for unambiguous study of true axon regeneration. The...
KEY FINDING: Knockdown of RhoA in vivo by retrogradely-delivered morpholino antisense oligonucleotides (MOs) to the RS neurons significantly reduced retrograde apoptosis signaling in identified RS neurons post-SCI.
The Journal of Spinal Cord Medicine, 2016 • January 1, 2016
This study explored the neuroprotective effects of local profound hypothermia and its mechanism of action after experimental spinal cord injury in rats. The results suggest that local profound hypothe...
KEY FINDING: Regional hypothermia downregulated the expressions of RhoA, ROCK-II, NG2, Neurocan, Brevican, and Nogo-A after spinal cord injury.
PLoS ONE, 2015 • September 14, 2015
This study examines the role of neurofilaments (NFs) in axon regeneration in lampreys after spinal cord injury (SCI) using antisense morpholino oligonucleotides (MOs) to manipulate NF expression. The ...
KEY FINDING: Inhibition of NF180 expression with antisense MOs significantly reduced axon regeneration at 4 and 9 weeks post-TX.
Neurosci Lett, 2017 • June 23, 2017
Spinal cord injury (SCI) is a debilitating condition with limited effective treatments to relieve neurological deficits, primarily due to the failure of long-distance regeneration of severed axons. Ap...
KEY FINDING: Axonal regeneration and sprouting can be enhanced by neutralizing myelin- and extracellular matrix-associated inhibitors.
PLoS ONE, 2015 • October 1, 2015
This study demonstrates the effectiveness of a combinatorial therapy (PNG+aFGF+ChABC) in improving lower urinary tract function in mice with complete spinal cord transection. The treatment led to redu...
KEY FINDING: The combination of PNG+aFGF+ChABC reduced bladder weight and improved bladder and external urethral sphincter histology.
Neural Plasticity, 2015 • July 1, 2015
This clinical trial investigated the safety and efficacy of human neural stem/progenitor cell (hNSPC) transplantation in patients with traumatic cervical spinal cord injury (SCI). Nineteen patients re...
KEY FINDING: hNSPC transplantation was safe and well-tolerated; no serious adverse events like tumor formation or neurological deterioration were observed.
Scientific Reports, 2017 • January 9, 2017
This study demonstrates the potential of aligned fibrin hydrogel (AFG) to promote spinal cord regeneration in canines with spinal cord injury (SCI). Tractography imaging revealed new nerve fibers grow...
KEY FINDING: Tractography revealed new fibers running across the spinal cord injury in three canines treated with AFG.
PNAS, 2017 • January 13, 2017
The study developed a platform technology using hMSCs and a PLGA matrix to improve donor cell survival and localized engraftment in vivo. The synthetic matrix supports hMSC survival, stemness, and fun...
KEY FINDING: PLGA scaffolding augments hMSC stemness, engraftment, and function without neural transdifferentiation or mesenchymal lineage development.
Neural Regeneration Research, 2015 • December 1, 2015
This study investigated the effects of electroacupuncture on spinal cord injury (SCI) recovery in rats, focusing on motor neuron function. The findings indicate that electroacupuncture increases acety...
KEY FINDING: Electroacupuncture increased AChE activity at the injury site in the spinal cord. This suggests improved nerve function and communication.
Restorative Neurology and Neuroscience, 2016 • January 1, 2016
This study examined the effect of choroid plexus epithelial cell (CPEC) transplantation on locomotor improvement and tissue repair in rats with spinal cord injury (SCI). The results showed that CPEC t...
KEY FINDING: Transplantation of CPECs significantly improved locomotor behaviors in rats with SCI, as measured by BBB scores.