Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN/AKT/mTOR pathway following spinal cord injury

This study investigates the use of exosomes, tiny vesicles released by cells, to treat spinal cord injuries. Specifically, the researchers modified mesenchymal stem cells (MSCs) to produce exosomes containing a specific molecule called miR-26a. They found that these modified exosomes (Exos-26a) can promote the regeneration of nerve fibers (axons) in rats with spinal cord injuries. This regeneration is facilitated by activating a specific signaling pathway involving PTEN, AKT, and mTOR proteins, which are crucial for cell growth and survival. The researchers suggest that using exosomes modified with miR-26a could be a promising new approach for treating spinal cord injuries by promoting nerve regeneration and reducing scar tissue formation.

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  Exosomes derived from miR-26a-modified MSCs (Exos-26a) promote axonal regeneration in a rat model of spinal cord injury.
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  Exos-26a improves neurogenesis and reduces glial scarring by modulating the PTEN/AKT/mTOR signaling pathway.
• 3
  Exos-26a treatment leads to better functional recovery in rats with spinal cord injuries, as evidenced by improved BBB scores, DTI images, and MEP amplitudes.