Regenerative Medicine Research

KEY FINDING: CaRheb expression promotes growth of axons into a peripheral nerve graft (PNG).

KEY FINDING: G-CSF stimulates neurogenesis, arteriogenesis in the CNS, and markedly improves long-term behavioral outcome after cortical ischemia or spinal cord injury.

KEY FINDING: MSCs exhibit anti-inflammatory activity, disease symptom amelioration, lesion reduction, and cellular death reduction/neuroprotection in various CNS diseases.

KEY FINDING: PirB immunoreactivity increased in the dorsal root ganglia, sciatic nerves, and spinal cord segments following unilateral spinal cord injury.

KEY FINDING: Following SCI, the re-expression of axon guidance molecules like ephrins, semaphorins, and Wnts can inhibit neural circuit plasticity and functional recovery.

KEY FINDING: Ischemic stroke, still causing high disability and mortality, prompted the investigation of therapeutic approaches other than thrombolytic therapy and/or percutaneous intravascular interventions. iPSCs have emerged as a promising tool for cell replacement in ischemic brain injuries.

KEY FINDING: Microglia are an important component of the protective scar that forms after SCI. Microglia form a dense cellular interface between reactive astrocytes and infiltrating monocyte-derived macrophages at the border of the lesion post-SCI.

KEY FINDING: A deep learning-based model can accurately identify differentiated cell types from brightfield images of NSCs as early as 1 day of culture.

KEY FINDING: Exercise increases regeneration into peripheral nerve grafts from propriospinal neurons but not sensory neurons after spinal cord injury.

KEY FINDING: Dextral hydrogel (DH) promotes neural differentiation of NSCs and improves neural regeneration in rat SCI models by regulating fatty acid metabolism of NSCs.