Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 681-690 of 2,298 results
Bioactive Materials, 2023 • January 1, 2023
This study synthesized layered double hydroxide (LDH) nanoparticles and optimized their ion elemental compositions to promote chondrogenic differentiation of human umbilical cord mesenchymal stem cell...
KEY FINDING: LDH nanoparticles with specific ion compositions (MgFe–NO3) effectively promoted chondrogenic differentiation of hUC-MSCs.
Front. Mol. Neurosci., 2015 • June 16, 2015
Repair of the injured spinal cord is a major challenge in medicine. The limited intrinsic regenerative response mounted by adult central nervous system (CNS) neurons is further hampered by astrogliosi...
KEY FINDING: CNS myelin contains myelin-associated inhibitors (MAIs) including Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp) that collapse axonal growth cones and inhibit growth.
Front. Mol. Neurosci., 2015 • June 18, 2015
It has become increasingly clear that there is no single pathway, protein, or drug that can promote robust axonal regeneration in the injured CNS, but our microarray analysis of the conditioning lesio...
KEY FINDING: ArgI activity was sufficient to mediate this response.
STEM CELLS AND DEVELOPMENT, 2015 • July 13, 2015
The study established a novel protocol to generate V3 interneurons (INs) from mouse embryonic stem cells (ESCs) by assessing the effects of increasing Shh signaling, prolonging the duration of Shh exp...
KEY FINDING: Lower concentrations of retinoic acid (RA) and a longer duration of smoothened agonist (SAG) exposure led to increased levels of p3 and V3 marker expression.
Neural Regeneration Research, 2015 • April 1, 2015
This study investigated the combined effects of propofol injection and bone marrow mesenchymal stem cell (BMSC) transplantation on spinal cord injury (SCI) in rats. The research demonstrated that the ...
KEY FINDING: The combination therapy significantly reduced the cavity size within the spinal cord compared to monotherapy or the control group.
Molecular & Cellular Proteomics, 2015 • July 16, 2015
This study characterized the secretome of USSC derived from hUCB, identifying 1156 proteins, including 31 known neurite growth promoting factors. Functional validation confirmed that SPARC and PEDF, s...
KEY FINDING: USSC secretome contains 1156 proteins, including 31 well-known neurite growth promoting factors.
American Journal of Pathology, 2015 • September 1, 2015
This study investigates the role of astrocyte activation, specifically via Stat3 signaling, in determining whether oligodendrocytes or Schwann cells are responsible for remyelination in the CNS after ...
KEY FINDING: Ablation of astrocyte activation leads to decreased oligodendrocyte-mediated remyelination.
Neural Regeneration Research, 2015 • June 1, 2015
This study investigated the effects of hydrogen-rich saline on spinal cord injury (SCI) in rats. Hydrogen-rich saline was administered into the subarachnoid space of rats after SCI. The results showed...
KEY FINDING: Hydrogen-rich saline markedly reduced cell death in the injured spinal cord tissue compared to the control group receiving physiological saline.
PLoS ONE, 2015 • July 29, 2015
The study modified an in vitro scarring model to study mechanisms of scar formation and reduction, and to investigate new scar-reducing treatments. The model uses a co-culture system of cerebral astr...
KEY FINDING: DFO treatment led to a significant reduction of scarring and slightly increased regeneration of corticospinal tract as well as ascending CGRP-positive axons.
Brain Res, 2016 • May 1, 2016
Stem cell therapies are being tested for various neurological diseases with the goal of regenerating damaged tissue and restoring lost function. While no stem cell therapy is currently approved, resea...
KEY FINDING: In demyelinating diseases and spinal cord injury, the primary goal is to remyelinate intact axons. MSC infusions have shown some improvement in neurologic function, possibly through immunomodulation.