Distribution of paired immunoglobulin-like receptor B in the nervous system related to regeneration difficulties after unilateral lumbar spinal cord injury

This study investigates the role of PirB, a receptor that inhibits nerve regeneration, after spinal cord injury in rats. The researchers aimed to understand why nerve regeneration is difficult after such injuries. The study found that PirB expression increased in areas like the dorsal root ganglia, sciatic nerves, and spinal cord segments after injury, suggesting PirB may play a role in suppressing nerve repair. By mapping the distribution of PirB, the researchers hope to better understand the mechanisms that prevent nerve regeneration after spinal cord injury and potentially identify new targets for therapies.

• 1
  PirB immunoreactivity increased in the dorsal root ganglia, sciatic nerves, and spinal cord segments following unilateral spinal cord injury.
• 2
  In the dorsal root ganglia and sciatic nerves, PirB was mainly distributed along neuronal and axonal membranes.
• 3
  Immunoreactivity for PirB was enhanced in some cortical neurons located in the bilateral precentral gyri.