Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis

This study investigates the potential of unrestricted somatic stem cells (USSC) from human umbilical cord blood (hUCB) to promote nerve regeneration. The researchers analyzed the proteins secreted by USSC (the secretome) and identified factors that could enhance neurite growth, which is important for nerve repair after spinal cord injury. They found that USSC secrete a variety of growth-promoting factors and proteins involved in processes like cell adhesion and blood vessel formation, suggesting a comprehensive regenerative capacity.

• 1
  USSC secretome contains 1156 proteins, including 31 well-known neurite growth promoting factors.
• 2
  SPARC and PEDF, secreted by USSC, were verified to be significantly involved in USSC-mediated neurite growth.
• 3
  USSC secretome contains proteins involved in nerve regeneration processes such as cell adhesion, cell motion, blood vessel formation, cytoskeleton organization, and extracellular matrix organization.