Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 671-680 of 2,298 results
Cell Transplantation, 2023 • August 21, 2023
This study demonstrates that cryopreserved olfactory ensheathing cells (OECs) can restore lost function in rats with dorsal root injuries, comparable to primary cultured OECs. The transplantation of c...
KEY FINDING: Transplantation of cryopreserved rat olfactory bulb OECs encapsulated in collagen restored the loss of function in a vertical climbing test in a unilateral C6-T1 dorsal root injury model.
Top Spinal Cord Inj Rehabil, 2023 • January 1, 2023
Translating regenerative therapies for spinal cord injury faces numerous hurdles, including the limitations of animal models, differences in injury characteristics, and the need for combinatorial trea...
KEY FINDING: Species differences, particularly in lesion characteristics, anatomy, and metabolism, pose significant challenges to translating findings from rodent models to humans with spinal cord injury.
Military Med Res, 2021 • May 12, 2021
This is a correction article addressing errors in figures in a previous publication regarding the conversion of astrocytes to motor neuron-like cells using small molecules. The corrected figures and s...
KEY FINDING: Small molecules can induce morphological changes in human astrocytes, converting them into neuron-like cells.
Cell Bioscience, 2021 • March 24, 2021
This study investigates the evolutionary divergence in tail regeneration between Xenopus laevis and Xenopus tropicalis. The researchers found that Xenopus tropicalis lacks the refractory period observ...
KEY FINDING: Xenopus laevis tadpoles exhibit a refractory period (stages 45-47) during which they cannot regenerate their tails after amputation.
Frontiers in Neuroscience, 2022 • December 13, 2022
Mesenchymal stem cells (MSCs) hold promise for central nervous system (CNS) regeneration due to their paracrine and immunomodulatory potential. They can promote immunomodulation, anti-apoptosis, and a...
KEY FINDING: MSCs exert immunomodulatory effects by secreting enzymes and soluble factors that act on various T lymphocytes, B cells, NK cells, and myeloid cells, disrupting their activation, proliferation, maturation, cytolytic activity, cytokine production, or antibody production.
Frontiers in Molecular Neuroscience, 2015 • June 11, 2015
CNS regeneration inhibitors play important physiological roles in the uninjured brain and spinal cord, regulating myelin formation, axon-myelin interactions, synapse formation, and activity-dependent ...
KEY FINDING: MAG plays a crucial role in the maintenance and long-term stability of the axon-glial unit, preventing axonal atrophy with age.
Cell and Tissue Research, 2022 • November 25, 2021
Rodent studies tracing endogenous NSCs in injuries and disease have revealed diversified roles for these cells depending on the model system. In SCI-based models, many endogenous NSCs have been found ...
KEY FINDING: Endogenous NSCs can contribute to reactive gliosis by differentiating into reactive astrocytes, while in other models, they can provide new myelination and neural replacement.
Int. J. Mol. Sci., 2022 • December 28, 2021
This study aimed to enhance rhBMP-2-mediated regeneration of critical sized segmental bone defects using a biomimetic silk fibroin scaffold. The scaffold was designed with anisotropic channel-like por...
KEY FINDING: Highly porous, anisotropic silk scaffolds were successfully produced and demonstrated good cytocompatibility in vitro.
Cell Death & Disease, 2021 • April 29, 2021
This study analyzed human umbilical-cord-derived MSCs from 32 donors and found donor-dependent variations in cell proliferation and immune modulatory functions, potentially explaining inconsistent cli...
KEY FINDING: Human umbilical cord-derived MSCs from 32 donors showed donor-dependent variations in proliferation and immune modulation capabilities.
The Journal of Neuroscience, 2015 • July 1, 2015
This study demonstrates that Pten deletion in postinjured adult corticospinal neurons enables a regenerative response in the mammalian spinal cord. Both the compensatory sprouting of intact CST axons ...
KEY FINDING: Pten deletion in adult mice promotes CST sprouting after unilateral pyramidotomy, as demonstrated by BDA tracing.