Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 661-670 of 2,298 results
Stem Cell Reports, 2023 • January 19, 2023
This study investigates the feasibility of using human pluripotent stem cell (hPSC)-derived spinal GABA neurons to treat spinal cord injury (SCI) in a nonhuman primate (NHP) model. The researchers est...
KEY FINDING: Human spinal GABA neurons, derived from pluripotent stem cells, can survive for up to 7.5 months after transplantation into the injured spinal cord of rhesus macaques.
Antioxidants, 2023 • January 7, 2023
Neurological disorders and injuries can impair nerve regeneration and functional recovery due to factors like inflammation and oxidative stress. Quercetin, a dietary flavonoid, possesses neuroprotecti...
KEY FINDING: Quercetin administration in SCI animal models reduced histopathological damage, inflammatory cytokine synthesis, and cellular oxidative stress.
Frontiers in Pharmacology, 2023 • January 10, 2023
This study investigates the therapeutic potential of iPSCs-Exo in treating spinal cord injury (SCI) in mice, focusing on the role of miR-199b-5p in modulating macrophage polarization and promoting neu...
KEY FINDING: iPSCs-Exo improves motor function in SCI mice and reduces the cavity volume in the injured spinal cord.
Brain Communications, 2023 • January 13, 2023
This study investigates the efficacy of epothilones (epoB and epoD) alone or in combination with rehabilitation for improving functional recovery after a moderate spinal cord injury (SCI) in rats. The...
KEY FINDING: Epothilone B (epoB) reduces fibrotic scarring, which can hinder axon regeneration, after a moderate spinal cord injury.
MedComm, 2023 • January 17, 2023
This review comprehensively summarizes the progress in functional research and application of NSC-EVs in different neurological diseases, including neurodegenerative diseases, acute neurological disea...
KEY FINDING: NSC-EVs can modulate various physiological and pathological processes, including neuroinflammation, neuroprotection, BBB integrity maintenance, neuroregeneration, and neurogenesis.
Open Medicine, 2023 • January 1, 2023
This study investigates the interaction between GPNMB and EGFR in regulating neural stem cell (NSC) survival and differentiation following spinal cord injury (SCI). The findings demonstrate that GPNMB...
KEY FINDING: GPNMB promotes neuronal viability and differentiation, as evidenced by increased expression of βIII tubulin and CNPase.
Cells, 2023 • February 14, 2023
This review analyzes experimental attempts to transform astrocytes into neurons (AtN) in adult animals, a strategy for CNS repair. The paper distinguishes between direct cell conversion and direct cel...
KEY FINDING: Direct cell conversion (1-2 TFs) and direct cell reprogramming (≥3 TFs or multifactor formulas) are proposed as distinct approaches to AtN, influencing the extent of epigenetic modification.
Stem Cells Translational Medicine, 2023 • March 9, 2023
NSPC transplantation represents a promising strategy for the regeneration of the injured spinal cord due to the ability of these cells to replace neural cells lost post-injury. We suggest using combin...
KEY FINDING: Integration is an important challenge related to neural stem/progenitor cell transplantation.
Stem Cell Investigation, 2023 • March 10, 2023
The review discusses the current status of regenerative medicine for spinal cord injury (SCI) using human induced pluripotent stem cells (iPSCs), highlighting the potential of iPSC-derived neural stem...
KEY FINDING: Transplanted iPSC-NS/PCs can engraft into the host spinal cord and differentiate into neurons, astrocytes, and oligodendrocytes, contributing to the reconstruction of neuronal circuits.
Front. Bioeng. Biotechnol., 2023 • March 13, 2023
Spinal cord injury (SCI) leads to sensory and motor dysfunction, with limited treatment options. Cell therapy shows promise but faces challenges. Exosomes, as paracrine factors released by cells, have...
KEY FINDING: Stem cell-derived exosomes have anti-inflammatory effects and can play a role in SCI treatment.