Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 611-620 of 2,298 results
Chinese Medicine, 2022 • July 5, 2022
This study investigates the neuroprotective effects of BSHX decoction on spinal cord injury recovery and the underlying mechanism. BSHX treatment could improve the microenvironment of the injured spin...
KEY FINDING: BSHX decoction improved motor function recovery in SCI mice.
Case Reports in Neurological Medicine, 2022 • July 6, 2022
This case report describes the successful recovery of voiding and sexual function in a patient with chronic complete spinal cord injury following olfactory ensheathing cell (OEC) transplantation combi...
KEY FINDING: The patient's ASIA Impairment Scale improved from ASIA A to ASIA C following OEC transplantation and neurorehabilitation.
Journal of Pain Research, 2022 • July 13, 2022
The study investigated the effects of regular exercise on neuropathic pain relief, the underlying mechanisms, and the impact of neuropathic pain on the hippocampus in a rat model. Results showed that ...
KEY FINDING: Regular exercise led to a significant reduction in pain hypersensitivity in rats with CCI at 5 weeks post-injury.
Frontiers in Molecular Neuroscience, 2022 • July 7, 2022
The study aimed to determine if gabapentinoids administration may synergize with cardiovascular-based efforts like treadmill training. The findings indicated that no additive, beneficial effect of volu...
KEY FINDING: Voluntary treadmill training did not enhance forelimb recovery in mice after cervical SCI, regardless of whether they were administered GBP or vehicle.
MedComm, 2022 • July 1, 2022
This study investigated the combined therapeutic effects of bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) on spinal cord injury (SCI) in mice. The results showed...
KEY FINDING: Combinational therapy of BMMSCs and PEMF displayed a more satisfactory effect than BMMSCs and PEMF therapy alone in SCI mice.
EMBO Reports, 2021 • August 24, 2021
This study investigates the role of Foxm1, a transcription factor, in spinal cord regeneration in Xenopus tropicalis tadpoles using bulk and single-cell RNA sequencing. The research finds that Foxm1 i...
KEY FINDING: Foxm1 is specifically expressed in the regenerating spinal cord of Xenopus tadpoles, peaking at 3 days post-amputation.
JCI Insight, 2022 • August 22, 2022
The study examines whether neural progenitor cell (NPC) grafts after chronic delays also support recovery and whether intensive rehabilitation further enhances recovery after severe bilateral cervical...
KEY FINDING: The combination of rehabilitation and NPC grafting significantly improved functional recovery in rats with chronic SCI, whereas either treatment alone was not effective.
Cells, 2022 • September 5, 2022
This study investigates the therapeutic potential of human induced pluripotent stem cell-derived neural progenitor cells (iPSC-NPCs) for treating cervical spinal cord injury (SCI) in rats. The key fin...
KEY FINDING: iPSC-NPCs were able to survive and differentiate into both neurons and astrocytes after transplantation into a cervical contusion SCI rat model.
in vivo, 2022 • July 12, 2022
This study investigates methods for culturing olfactory ensheathing cells (OECs) using materials and reagents certified for pharmaceutical use, aiming to produce advanced cell therapies for humans wit...
KEY FINDING: Acid-solubilized collagen (ASC) is superior to pepsin-solubilized collagen (PSC) for creating 3D collagen scaffolds, as ASC provides easier handling during surgical procedures.
Journal of Immunology Research, 2022 • September 12, 2022
This paper argues that a miR-34a-3p/PDCD6 axis might be a candidate therapeutic target for treating SCI and that the therapeutic effect of EA is driven through this pathway. The results revealed that m...
KEY FINDING: miR-34a-3p might promote the in vitro differentiation of neural stem cell (NSC) through suppressing PDCD6 and regulating other important neural markers such as fibroblast growth factor receptor 1 (FGFR1), MAP1/2 (MAP kinase kinases 1/2), myelin basic protein (MBP), βIII-tubulin Class III β-tubulin (βIII tubulin), and glial fibrillary acidic protein (GFAP).