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  4. Recovering Voiding and Sex Function in a Patient with Chronic Complete Spinal Cord Injury by Olfactory Ensheathing Cell Transplantation

Recovering Voiding and Sex Function in a Patient with Chronic Complete Spinal Cord Injury by Olfactory Ensheathing Cell Transplantation

Case Reports in Neurological Medicine, 2022 · DOI: https://doi.org/10.1155/2022/9496652 · Published: July 6, 2022

Spinal Cord InjuryRegenerative Medicine

Simple Explanation

This case report discusses a patient with a complete spinal cord injury who received olfactory ensheathing cell (OEC) transplantation. The patient experienced improvements in motor function, sensation, and activities of daily living after the transplantation. Specifically, the patient regained the ability to control urination and recovered normal sexual function after the OEC transplantation and subsequent neurorehabilitation. He was able to marry and father a child through natural sexual intercourse. The positive outcomes observed in this case highlight the potential of OEC transplantation as a neurorestorative therapy for individuals with chronic complete spinal cord injuries, although further research is needed to understand why some patients benefit more than others.

Study Duration
6 Years
Participants
1 Male patient with complete SCI
Evidence Level
Level 4: Case Report

Key Findings

  • 1
    The patient's ASIA Impairment Scale improved from ASIA A to ASIA C following OEC transplantation and neurorehabilitation.
  • 2
    The patient's International Association of Neurorestoratology Spinal Cord Injury Functional Rating Scale (IANR-SCIFRS) score increased from 14 to 31 + 3 (for sex function) after cell therapy.
  • 3
    The patient regained the ability to perform daily activities such as eating, dressing, and writing independently, as well as standing and walking with assistance.

Research Summary

This case report describes the successful recovery of voiding and sexual function in a patient with chronic complete spinal cord injury following olfactory ensheathing cell (OEC) transplantation combined with intensive neurorehabilitation. The patient, who had a traumatic SCI at the C6-C7 level, showed improvements in motor function, sensation, and activities of daily living, including urine control and sexual activity, after the cell treatment and rehabilitation. The authors conclude that OEC transplantation may offer a promising neurorestorative approach for improving neurological function in patients with chronic complete SCI, but further studies are needed to understand the underlying mechanisms and variability in patient responses.

Practical Implications

Neurorestorative Potential

OEC transplantation may be a viable therapeutic option for patients with chronic complete SCI, particularly for recovering voiding and sexual function.

Combination Therapy

Intensive neurorehabilitation alongside OEC transplantation appears crucial for maximizing functional recovery in SCI patients.

Personalized Treatment

Further research is needed to identify factors that predict which patients are most likely to benefit from OEC transplantation.

Study Limitations

  • 1
    Single case report limits generalizability
  • 2
    Unknown mechanisms for varied patient responses
  • 3
    Long-term effects require further investigation

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