Regenerative Medicine Research

KEY FINDING: Low-energy ESWT had a dose-dependent effect, with three treatment sessions (ESWT3) showing superior outcomes compared to a single session.

KEY FINDING: The intravenous infusion of autologous MSCs expanded in auto-serum is a safe and feasible therapeutic approach for chronic SCI patients.

KEY FINDING: The combined therapy of hUCMSCs/NSCs transplantation and EES significantly improved motor function recovery compared to either treatment alone in mice with spinal cord crush injuries.

KEY FINDING: cBMMSC transplantation based on nanosilver hydrogel nerve conduit was effective in repairing spinal cord injury, promoting neuronal and axonal regeneration, and restoring neuromotor and electrophysiological functions.

KEY FINDING: BMMSCs improve motor function recovery in SCI rats, as evidenced by increased BBB scores and improved footprint analysis.

KEY FINDING: Both cBMMSC and sc-cBMMSC transplantation substantially improved rod-rotating time in cuprizone-induced demyelination mice, with a more significant effect observed in the sc-cBMMSC group.

KEY FINDING: Motor function, as measured by the BBB score, improved significantly more in the swimming group compared to the sedentary group at 3 and 6 weeks after SCI.

KEY FINDING: iNSCs demonstrate potential for direct neural regeneration and integration with host spinal cord tissue, offering advantages over other cellular therapies.

KEY FINDING: iPSCs can be differentiated into various cell types that play crucial roles in SCI treatment, including neural progenitor cells, oligodendrocyte progenitor cells, astrocytes, and microglia.

KEY FINDING: The PRP injection, combined with exercise, led to significant decreases in shoulder pain, as measured by the WUSPI, NRS, and physical exam scores, 24 weeks after treatment.