Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury

Spinal cord ischemia-reperfusion injury (IR) is a severe condition that can occur after abdominal aortic occlusion, leading to neurological damage. The study investigates whether exosomes derived from human placental mesenchymal stem cells (hpMSCs-Exos), combined with hyperbaric oxygen (HBO), can reduce injury and improve recovery in rats with IR. The researchers found that the combined treatment (hpMSCs-Exos + HBO) led to better neurological function, increased neuron density, higher levels of antioxidative factors, and reduced inflammation compared to the IR group alone. The study suggests that using hpMSCs-Exos and HBO together has a synergistic neuroprotective effect in rats with IR, meaning the combination is more effective than either treatment alone.

• 1
  The combination of hpMSCs-Exos and HBO significantly increased neuronal survival and decreased gliosis (proliferation of glial cells) in the spinal cord.
• 2
  The combined treatment inhibited IR-induced oxidative stress, as evidenced by increased levels of antioxidative factors (GSH, SOD, CAT) and decreased levels of the oxidative factor MDA.
• 3
  The combination therapy reduced inflammation by increasing the anti-inflammatory cytokine IL-10 and decreasing pro-inflammatory cytokines (IL-1b, TNF-a, IL-18).