Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 521-530 of 2,298 results
Neural Regen Res, 2023 • May 1, 2023
This study demonstrates that combining bone marrow mesenchymal stem cell (BMMSC) transplantation with exercise training (TMT) synergistically improves motor function recovery in mice after spinal cord...
KEY FINDING: The combination of bone marrow mesenchymal stem cell transplantation and exercise training showed a better therapeutic effect on motor function than the single treatments.
Neural Regeneration Research, 2023 • November 25, 2022
The study investigated the effects of exercise combined with adipose-derived stem cells (ADSCs) on neuropathic pain after spinal cord injury (SCI) in a mouse model. The results demonstrated that the c...
KEY FINDING: Exercise combined with ADSC administration partially improved early motor function recovery after SCI.
Neural Regen Res, 2023 • January 30, 2023
Spinal cord injury leads to neuronal death, with ferroptosis being a key contributor to dysfunction. Emerging treatments like MSC, EV, and TMS therapy offer hope by potentially inhibiting neuronal dea...
KEY FINDING: Ferroptosis, a form of cell death, significantly contributes to neurological dysfunction following spinal cord injury.
Neural Regeneration Research, 2023 • January 5, 2023
The study investigates the role of gecko HSF1 (gHSF1) in regulating neurite outgrowth and inflammatory inhibition of macrophages following spinal cord injury using a gecko model. Results showed that g...
KEY FINDING: gHSF1 expression in neurons and microglia at the lesion site increased dramatically immediately after tail amputation.
Biomedicines, 2023 • May 8, 2023
This study investigated the effects of human adipose-derived stem cells (ADSC) on spinal cord injury (SCI) in rats. ADSC were infused into rats with SCI, and the researchers assessed cellular changes ...
KEY FINDING: The stem cells were observed migrating towards the injury site in the spinal cord.
Front. Neurol., 2023 • May 23, 2023
This study investigated the effects of plasma-synthesized polypyrrole/iodine (PPy/I) alone and in combination with swimming and enriched environment (SW/EE) rehabilitation on gene expression and locom...
KEY FINDING: PPy/I treatment upregulated genes related to developmental processes, biogenesis, synapses, and synaptic vesicle trafficking, suggesting a role in nerve regeneration and synaptic plasticity.
Clinical and Translational Medicine, 2023 • May 21, 2023
This study investigates the therapeutic effects of intravenous delivery of small extracellular vesicles (sEVs) derived from human mesenchymal stem/stromal cells (MSC) on body growth and motor recovery...
KEY FINDING: Intravenous delivery of human and rat MSC-sEVs improved functional motor recovery after SCI and restored normal body growth in young adult SCI rats.
World Journal of Stem Cells, 2023 • May 26, 2023
This review highlights the therapeutic potential of BMMSCs in treating SCI by summarizing their applications based on mechanisms like neuroprotection, axon regeneration, myelin repair, immunomodulatio...
KEY FINDING: BMMSCs exhibit neuroprotective effects by releasing growth and neurotrophic factors like BDNF, VEGF, and GDNF, enhancing regeneration and repair in damaged tissues.
Frontiers in Immunology, 2023 • June 14, 2023
This study investigates the therapeutic mechanisms of transcranial intermittent theta-burst stimulation (iTBS) on nerve regeneration and functional recovery in rats with complete spinal cord transecti...
KEY FINDING: Transcranial iTBS reduces inflammation and neuronal apoptosis in the sensorimotor cortex (SMC) following spinal cord injury.
North American Spine Society Journal (NASSJ), 2023 • June 8, 2023
This review summarizes the key advances in the field of neural regeneration and neuroplasticity. Regenerative medicine shows promise to help enhance tissue regeneration following SCI, with various cel...
KEY FINDING: Spinal interneuron reorganizations are subtype specific and may be adaptive or maladaptive for a given functional output.