Immediate administration of hTERT-MSCs-IDO1-EVs reduces hypoalbuminemia after spinal cord injury

Spinal cord injury can lead to inflammation and reduced levels of serum albumin, a protein important for maintaining fluid balance and transporting substances in the blood. This study investigates whether extracellular vesicles (EVs) from modified stem cells can help improve serum albumin levels after spinal cord injury. The researchers used EVs from human adipose tissue-derived mesenchymal stem cells (hTERT-MSCs) that were modified to express a gene called IDO1. They injected these EVs into rats immediately after they experienced a spinal cord injury. The results showed that the rats that received IDO1-EVs had higher levels of serum albumin and glucose compared to the rats that did not receive the treatment, suggesting that IDO1-EVs may have beneficial effects in reducing hypoalbuminemia and improving energy consumption after spinal cord injury.

• 1
  The level of serum albumin in the animals that received IDO1-EVs was increased compared to the SCI group, suggesting a reduction in hypoalbuminemia.
• 2
  Animals treated with IDO1-EVs showed higher glucose levels in their serum compared to the SCI group, indicating improved energy consumption.
• 3
  The administration of hTERT-MSCs-IDO1-EVs in a rat model of SCI improves the functional recovery of rats in comparison with other experimental groups.