The Efficacy of Different Material Scaffold‑Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta‑analysis

Cell transplantation is a promising treatment for spinal cord injury (SCI), but the best carrier scaffolds for cells are unclear. This study evaluates the effectiveness of different material scaffolds in cell transplantation for SCI treatment in rats. The study analyzed 25 articles, finding that both natural and synthetic scaffolds improved motor function in SCI rats. However, there were no significant differences between the two scaffold types. The number and type of cells may be important factors in therapeutic efficacy. Future research should validate these findings in clinical trials.

• 1
  Both natural and synthetic scaffold-driven cell transplantation are superior to the control group in treating SCI rats, with statistically significant differences.
• 2
  Synthetic scaffolds are slightly inferior to natural scaffolds in terms of restoring motor function in cell transplantation of SCI rats.
• 3
  The type and number of cells may be important factors in therapeutic efficacy.