Frontiers in Neurology, 2025 · DOI: 10.3389/fneur.2025.1447414 · Published: January 24, 2025
This study reviews existing research on using exosomes from mesenchymal stem cells (MSC-exos) to treat spinal cord injuries (SCI) in animal models. The aim is to understand how effective these exosomes are in helping rats recover from SCI. The research team looked at studies that used exosomes derived from different sources like bone marrow, fat tissue, and umbilical cords. They analyzed how well the rats recovered motor function after receiving exosome treatment compared to a control group. The study found that MSC-exos, especially those from bone marrow, showed promise in improving motor function in rats with SCI. This suggests that exosomes could be a potential therapy for SCI, but more research is needed.
MSC-exos could be a promising therapeutic strategy for improving motor function recovery in individuals with SCI.
High-quality, direct comparative studies are needed to identify the optimal stem cell sources for exosome-based therapy.
Addressing limitations related to publication bias, data standardization, and exosome extraction methods is crucial for translating these findings into clinical applications.