Regenerative Medicine Research

KEY FINDING: Molecules derived from myelin inhibit axon outgrowth. A high-molecular-weight membrane protein (NI-35/250) has been found in rat, bovine, and human myelin as a main neurite growth inhibitory factor.

KEY FINDING: Wnt5a enhances neuronal differentiation of BMSCs in vitro while reducing astrocyte differentiation.

KEY FINDING: NG2 cells possess an inducible neurogenic potential in animal models and in vitro, and this can be promoted by pharmacological and genetic approaches.

KEY FINDING: The most common adverse events were transient backache and meningism (90%) and cord malacia (80%).

KEY FINDING: Stem cell-based transplantation shows promise due to direct tissue replacement, neuroprotection, and support for axonal regrowth and neuronal plasticity.

KEY FINDING: Chondroitinase ABC (ChABC) treatment effectively degraded CSPGs, reduced glial response, and promoted the migration of grafted Schwann cells (SCs) in the injured spinal cord.

KEY FINDING: A single CM administration to the cerebellum had a mild effect on the balance and motor deficits of SCA3/MJD mice.

KEY FINDING: All four subjects tolerated the stem cell implantation procedure well, with no serious adverse events immediately following the procedure.

KEY FINDING: Intracellular iron levels are significantly different between iPSCs and SCPCs, allowing MRR to distinguish between the two cell types based on T2 values.

KEY FINDING: TET3 enhances HUCMSC differentiation into OPCs, evidenced by specific marker expression.