Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 281-290 of 2,298 results
Neural Regen Res, 2012 • November 1, 2012
This study investigated the effects of silencing the C/EBP homologous protein (CHOP) gene on acute brain injury following ischemia/reperfusion in rat models. The results showed that silencing CHOP sig...
KEY FINDING: Silencing C/EBP homologous protein gene expression significantly reduced cerebral infarction volume in rats following cerebral ischemia/reperfusion.
International Journal of Molecular Sciences, 2014 • October 28, 2014
The study aimed to evaluate whether combining ventral root reimplantation with bone marrow mononuclear cell (MC) therapy could improve long-term nerve regeneration and synaptic recovery after ventral ...
KEY FINDING: Root reimplantation preserves synaptic inputs, as shown by ultrastructural analysis of the spinal cord, leading to a close to normal synaptic covering compared to the avulsed group.
Frontiers in Cell and Developmental Biology, 2014 • August 13, 2014
This perspective article examines neuronal differentiation and the characterization of neural progenitors derived from human embryonic stem cells for neural regeneration. The authors present a cell mo...
KEY FINDING: hESC-derived NPs can exhibit spontaneous and evoked activity, indicating their electrophysiological and calcium handling properties are similar to matured neurons.
Frontiers in Neuroscience, 2014 • October 22, 2014
Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such as migration, dendrite developm...
KEY FINDING: RhoA/ROCK signaling is involved in various central nervous system (CNS) diseases, including optic nerve and spinal cord injuries, stroke, and neurodegenerative diseases.
Neural Regeneration Research, 2014 • September 1, 2014
This study investigates the protective effects of bone marrow mesenchymal stem cells (BMSCs) on spinal cord ischemia/reperfusion injury in rats. The researchers found that BMSC transplantation promote...
KEY FINDING: Transplanted bone marrow mesenchymal stem cells increased the expression of axonal regeneration marker growth associated protein-43.
Neural Regeneration Research, 2014 • September 1, 2014
This study investigates the impact of craniocerebral injury on peripheral nerve repair, building on previous findings that brain injury can promote fracture healing due to increased neurotrophic facto...
KEY FINDING: Rats with combined sciatic and craniocerebral injuries showed decreased sciatic functional index compared to those with sciatic nerve injury alone.
Neural Regen Res, 2014 • September 1, 2014
This study investigates the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors using a rat sciatic nerve crush model. The results indicate that edaravone promotes ...
KEY FINDING: Edaravone increased the sciatic functional index in rats with sciatic nerve injury, indicating improved motor function.
Stem Cell Research & Therapy, 2014 • November 17, 2014
This study investigated the safety and potential effectiveness of using mesenchymal stem cells (MSCs) derived from a patient’s own bone marrow to treat chronic spinal cord injuries (SCI). The study fo...
KEY FINDING: The study found that transplanting bone marrow-derived mesenchymal stem cells into the injured spinal cord was generally a safe procedure for individuals with chronic, complete spinal cord injury.
Neural Regeneration Research, 2014 • October 1, 2014
This meta-analysis evaluated the effects of olfactory ensheathing cell transplantation on functional recovery of rats with complete spinal cord transection. Six randomized controlled trials were inclu...
KEY FINDING: Meta-analysis demonstrated that BBB scores were significantly higher in the olfactory ensheathing cell transplantation group compared with the control group.
Cold Spring Harb Perspect Biol, 2015 • January 1, 2015
The review focuses on how oligodendrocytes, astrocytes, and microglia contribute to the failure of axon regeneration in the injured CNS, particularly in the spinal cord. Oligodendrocytes inhibit regen...
KEY FINDING: Oligodendrocytes and CNS myelin inhibit neurite regeneration, compensatory growth, and plasticity through myelin-associated growth inhibitory factors.