Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,121-2,130 of 2,298 results
The Journal of Neuroscience, 2004 • September 8, 2004
This study investigates the role of L1.1, a homolog of the mammalian recognition molecule L1, in spinal cord regeneration in adult zebrafish. Using a morpholino-based approach, the researchers reduced...
KEY FINDING: Reducing L1.1 protein expression impairs locomotor recovery in adult zebrafish after spinal cord transection.
J Comp Neurol, 2004 • October 25, 2004
This study investigates the effects of conditioning lesions (CLs) on axonal regeneration of descending brain neurons in spinal-cord-transected larval lamprey. The researchers found that CLs at 30% bod...
KEY FINDING: Conditioning lesions at 30% body length, with a two-week delay before a test lesion and a four-week recovery period, significantly enhanced axonal regeneration of descending brain neurons.
The Journal of Neuroscience, 2004 • September 29, 2004
This study investigates the potential of olfactory ensheathing cells (OECs) to repair spinal cord injuries. OECs from adult transgenic rats were transplanted into a dorsal spinal cord transection lesi...
KEY FINDING: Transplanted OECs survived within the lesion zone and oriented longitudinally along axons bridging the transection site.
The Journal of Experimental Medicine, 2004 • October 18, 2004
This study demonstrates that a single neuroinflammatory lesion in the spinal cord induces axonal remodeling at multiple levels within the motor system. The remodeling includes local interneuron sprout...
KEY FINDING: Local interneurons near the spinal cord lesion sprout new connections, indicated by increased expression of c-Jun and GAP43.
The Journal of Neuroscience, 2004 • November 3, 2004
This study investigates the feasibility of using superparamagnetic iron oxide (SPIO)-labeled Schwann cells (SCs) and olfactory ensheathing cells (OECs) for non-invasive tracking via MRI after transpla...
KEY FINDING: SCs and OECs efficiently internalize dextran-coated SPIO from the culture medium by fluid phase pinocytosis.
The Journal of Neuroscience, 2004 • November 10, 2004
This study demonstrates that mice lacking EphA4 exhibit axonal regeneration and functional recovery after spinal cord injury, including improved motor skills. The absence of EphA4 leads to reduced ast...
KEY FINDING: EphA4-deficient mice exhibit axonal regeneration and functional recovery after spinal cord hemisection, including improvements in stride length, grid walking, and grasping ability.
Exp Neurol, 2005 • March 1, 2005
The study examined the response of endogenous oligodendrocyte precursor cells (OPCs) following ethidium bromide (EB)-induced demyelination of the adult rat spinal cord. A robust mobilization of highly...
KEY FINDING: Nkx2.2+/Olig2+ OPCs are recruited to demyelinated lesions but fail to remyelinate axons in regions lacking astrocytes.
The Journal of Neuroscience, 2005 • February 16, 2005
This study investigates the role of STAT3 activation in conditioning injury-induced spinal axon regeneration. The researchers found that sciatic nerve transection, but not dorsal column crush, leads t...
KEY FINDING: Sciatic nerve transection induces persistent STAT3 phosphorylation in DRG neurons in vivo, while dorsal column crush does not.
Mol Cell Neurosci, 2005 • May 1, 2005
This study demonstrates that transgenic expression of a secreted function-blocking NgR protein has profound effects after SCI, stimulating both CST and raphespinal fiber growth in the injured spinal c...
KEY FINDING: Transgenic mice expressing NgR(310)ecto showed increased CST fiber growth into the caudal spinal cord after dorsal over-hemisection compared to wild-type mice.
J Control Release, 2005 • June 2, 2005
This report, single lumen and multiple lumen conduits capable of controlled, sustained release of neurotrophic factors were fabricated, and have potential application in nerve regeneration. These cond...
KEY FINDING: The porosity and mechanical properties of the constructs were regulated by the ratio of porogen to polymer microsphere.