Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,131-2,140 of 2,298 results
Cellular and Molecular Neurobiology, 2005 • April 1, 2005
The study comprehensively screens for genes that change their expression during the brief critical period in development when the neonatal mammalian central nervous system (CNS) loses its capacity to ...
KEY FINDING: The study identified a set of genes that are differentially expressed in regenerating versus non-regenerating spinal cords of neonatal opossums, including novel sequences and genes involved in cell growth, motility, and myelin formation.
Eur J Neurosci, 2005 • August 1, 2005
The study investigates the combined effects of methylprednisolone (MP) and soluble Nogo-66 receptor (NgR) on spinal cord injury (SCI) recovery in rats, using a dorsal hemisection model. Both MP and Ng...
KEY FINDING: Combined treatment with NgR(310)ecto-Fc and MP had a more pronounced effect on recovery of function and axonal growth compared with either treatment alone.
The Journal of Neuroscience, 2005 • August 31, 2005
The study investigates strategies to promote sensory axon regeneration in the injured spinal cord, focusing on overcoming inhibitory factors and enhancing neuronal growth capacity. The key finding is ...
KEY FINDING: Inflammation-induced preconditioning of sensory neurons combined with enzymatic degradation of inhibitory proteoglycans (CSPGs) significantly enhances axonal regeneration through the DREZ.
Glia, 2006 • March 1, 2006
This study investigates the neuroprotective effects of olfactory ensheathing cell (OEC) transplantation on corticospinal tract (CST) neurons after dorsal spinal cord transection in rats. The results d...
KEY FINDING: OEC transplantation reduces the number of apoptotic cortical neurons at 1 week post-transplantation.
Eur Spine J, 2006 • November 15, 2005
This study assessed a new composite implant to induce regeneration of injured spinal cord in paraplegic rats following complete cord transection. Implants of adult human NOM cells were implanted into ...
KEY FINDING: Rats with complete spinal cord transection showed partial recovery of function after implantation with a composite implant containing either adult human nasal olfactory mucosa cells or human embryonic spinal cord cells.
BMC Neuroscience, 2006 • January 24, 2006
The study investigated the effects of LPS-induced inflammation on the expression of growth-associated genes in corticospinal neurons and the potential for axonal regeneration after spinal cord injury....
KEY FINDING: Application of LPS induced a gradient of inflammation throughout the motor cortex.
The Journal of Neuroscience, 2006 • February 8, 2006
This study demonstrates that transplanted GFP-OECs can remyelinate demyelinated spinal cord axons and establish structurally intact nodes of Ranvier. The remyelinated axons exhibit appropriate cluster...
KEY FINDING: Transplanted olfactory ensheathing cells (OECs) remyelinate demyelinated axons in the spinal cord and promote the formation of structurally intact nodes of Ranvier.
The Journal of Neuroscience, 2006 • March 29, 2006
This study investigates the potential of adult brain-derived neural precursor cells (NPCs) to promote remyelination and functional recovery after spinal cord injury (SCI) in rats. The researchers tran...
KEY FINDING: Transplanted adult neural precursor cells (NPCs) survived better in the injured spinal cord when transplanted during the subacute phase of injury compared to the chronic phase.
The Journal of Cell Biology, 2006 • April 10, 2006
This study identifies repulsive guidance molecule A (RGMa) as a potent inhibitor of axon regeneration in the adult central nervous system (CNS). RGMa inhibits neurite outgrowth through the RhoA-Rho ki...
KEY FINDING: RGMa inhibits mammalian CNS neurite outgrowth by activating the RhoA–Rho kinase pathway, a key signaling pathway involved in growth cone collapse and axon repulsion.
Cellular and Molecular Neurobiology, 2006 • April 22, 2006
This study examines the potential of autologous adult stem cell transplantation and polymer scaffolds for spinal cord regeneration. It compares the effects of intravenous injections of mesenchymal ste...
KEY FINDING: In rats, MSC and BMC treatments led to smaller lesions, improved motor function, and faster recovery of sensitivity in hind limbs. MSC treatment showed more pronounced functional improvement.